Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study

Table 2 Linear mixed models, analyzing variation of lymphocytes, neutrophils, and neutrophils to lymphocytes-ratio, according to age, sex, and across study follow-up.

			Lymphocytes coefficient (SE)	p-value	Neutrophils coefficient (SE)	p-value	Log-NL-ratio coefficient (SE)	p-value
Initial status	Intercept	γ ₀₀	2.634 (0.245)	< 0.001	2.703 (0.459)	< 0.001	0.021 (0.153)	0.89
	Age	γ ₀₁	-0.009 (0.003)	0.02	0.017 (0.007)	0.008	0.009 (0.002)	< 0.001
	Sex	γ ₀₂	-0.107 (0.148)	0.47	0.613 (0.275)	0.03	0.215 (0.092)	0.02
Rate of change	Intercept	γ ₁₀	-0.008 (0.031)	0.80	-0.089 (0.063)	0.16	-0.027 (0.020)	0.19
	Interaction Time*Age	γ ₁₁	-0.0006 (0.0004)	0.14	0.0014 (0.0008)	0.08	0.0008 (0.0003)	0.002
	Interaction Time*Sex	γ ₁₂	0.018 (0.012)	0.15	0.003 (0.025)	0.90	-0.009 (0.008)	0.28
	Interaction Age*Sex	γ ₁₃	0.001 (0.002)	0.87	-0.011 (0.004)	0.006	-0.003 (0.001)	0.02
Level 1	Within person	δ ²_ε	0.107 (0.003)	< 0.001	0.678 (0.021)	< 0.001	0.069 (0.002)	< 0.001
Level 2	In initial status	δ ²₀	0.354 (0.021)	< 0.001	1.036 (0.086)	< 0.001	0.113 (0.009)	< 0.001
	In rate of change	δ ²₁	0.020 (0.002)	< 0.001	0.053 (0.008)	< 0.001	0.006 (0.001)	< 0.001
	Covariance	δ ₀₁	-0.034 (0.005)	< 0.001	-0.089 (0.023)	< 0.001	-0.009 (0.002)	< 0.001
		AIC	6627		13824		3540
		BIC	6685		13882		3598

Note Abbreviations: γ₀₀ = intercept of the average trajectory; γ₀₁ = intercept of the age trajectory; γ₀₂ = intercept of the sex trajectory; γ₁₀ = intercept time effect of the trajectory for the time of the study effect; γ₁₁ = slope of the trajectory for the interaction between time and age; γ₁₂ = slope of the trajectory for the interaction between time and sex; γ13 = slope of the trajectory for the interaction between age and sex; δ²_e = within-person variance components; δ²₀ = in initial status variance components; δ²₁ = in rate of change variance components; δ₀₁ = covariance estimate; AIC = Akaike information criterion; BIC = Bayesian information criterion.

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