Fig. 3

Heatmaps of age-related gene expression changes in the mouse and human lung. A Examples of significantly regulated genes from the linear regression model. The data are based on 89 individual mouse samples and the dendrogram separates the different age groups. B Examples of significantly regulated genes from the linear regression model. The data are based on 74 mice aged 6–26 and 52–130 weeks, and the dendrogram separates the different age groups. C Examples for significantly regulated genes from the linear regression model for the human test set. Note, we selected 17 individuals based on the maximum difference in age, i.e. < 50 years and > 80 years. D Examples for significantly regulated genes from the linear regression model for the human validation set. Note, we selected 51 individuals based on the maximum difference in age, i.e. < 50 years and > 80 years