Fig. 4

Enrichment analysis of age-related gene expression changes. Based on the linear regression model we identified significantly regulated genes in the aging lung of mice and humans. A Shown are significantly enriched GO terms for upregulated genes of N = 74 individual mice aged 6–130 weeks. B Shown are significantly enriched GO terms for down-regulated genes of N = 74 individual mice. C Shown are significantly enriched GO terms for upregulated genes of N = 307 individual human donors aged 21 – 85 years. D Shown are significantly enriched GO terms for down-regulated genes of N = 307 individual human donors aged 21 – 85 years. Abbreviations: SP (signaling pathway), GF (growth factor), R.(receptor), res. (response), act.(activation), con. (concentration), pos. (positive), reg. (regulation), sig. (signaling), imm. (immune), org. (organization), net. (network)