Fig. 6

Gene expression changes of the aging human lung. Based on the linear regression model for N = 307 individual human genomic data sets (mice aged 21–85 years old), we identified 857 and 816 genes, respectively whose expression increased or declined with age (p < 0.05). Among the upregulated genes, 80 code for ECM remodeling, notably collagens (N = 13), proteoglycans (N = 7), matrix metalloproteinase (N = 4) and ECM-related glycoproteins (N = 33). We also include 10 genes coding for the inflammatory response pathway. Panel A1: Boxplot of 857 DEGs with increased expression over time. Panel A2: Boxplots of upregulated genes coding for ECM remodeling and immune response. B Regulation of individual genes with age. The genes refer to the data shown in the boxplots of A2 for the various ontology terms. Panel C1: Boxplot of 816 DEGs with decreased expression over time. Panel C2: Boxplots of down-regulated genes coding for cell morphogenesis, microtubule cytoskeleton organization, tight junction assembly, lipid transport and PPAR signaling. D Regulation of individual genes with age. The genes refer to the data shown in the boxplots of C2 for the various ontology terms