Fig. 3
From: Towards a better preclinical cancer model – human immune aging in humanized mice
Single cell RNA sequencing analysis of splenocytes. A tSNE plot showing nine graph-based clusters that potentially represent different human immune subsets found in splenocytes harvested from aging (55-week-old) and young (14-week-old) humanized mice. Table shows top ten expressed genes for each cluster with likely cell type in parenthesis. B Gene set enrichment analysis of genes that were up- or down-regulated by at least twofold. Top ten enriched GOs are shown for CD8+ cells in Cluster 1, CD4+ cells in Cluster 2, CD4+ cells in Cluster 3 and CD4+ cells in Cluster 6. p values are indicated