Fig. 4

Sex differences in TREM2 and APOE levels in patient-specific Mo-MФs. Fold increase in a TREM2 mRNA, b sTREM2 and c APOE levels in Mo-MФ cultures from AD-female patients (n = 10) vs. AD-male patients (n = 11) after long-term compared to short-term differentiation in AS. Fold increase in d TREM2 mRNA, e sTREM2 and f APOE levels in Mo-MФs cultures from CO-female patients (n = 11) vs. CO-male patients (n = 5) after long-term compared to short-term differentiation in AS. a-f Closed bars and circle symbols represent male (dark grey for AD, light grey for CO) or female (dark orange for AD, light orange for CO) patients. mRNA (normalized to GAPDH) expression was measured with RT-qPCR. A pairwise comparison of groups was performed with the Mann Whitney U-test (paired groups) (*p < 0.05, **p < 0.01, ***p < 0.001)