Fig. 2

Pathway analysis of immunology proteins associated with the metabolic process in bone. Functional protein network analysis of significant proteins associated with metabolic process. The STRING version 11 was used to create the network analysis (https://string-db.org/). In the network, each protein is represented by a coloured node, and protein–protein interaction and association are represented by an edge visualized as a coloured lined (type of interaction). Known interactions used were from curated databases (turquoise) and experimentally determined (pink). Predicted interactions were gene neighbourhood (green), gene fusion (red) and gene-co-occurrence (dark blue), and other interactions were text mining (yellow), coexpression (black), and protein homology (purple). Interleukin 6 (IL-6), Lymphotoxin-alpha (LT-α) or tumor necrosis factor-beta (TNF-β), Fms-related tyrosine kinase 3 ligand (FLT3LG), Colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), and Chemokine (C-C motif) ligand 7 (CCL7)