Fig. 3

Group difference (fracture vs. non-fracture) and their association with FRAX (hip and major) score with significant plasma biomarkers. Panel A, D, G, J and M show mean plots of the five proteins with the most significant changes in protein expression levels following t-tests between fracture vs. non-fracture groups. Panel B, C, E, F, H, I, K, L, N, and O figures, show the lineal regression between fracture vs. non-fracture groups with FRAX (hip and major) scores with significant plasma biomarkers. Solid lines: estimation; dashed curved lines: 95% confidence interval limits. Lymphotoxin-alpha (LT-α) or tumor necrosis factor-beta (TNF-β), Fms-related tyrosine kinase 3 ligand (FLT3LG), Interleukin 6 (IL-6), Colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), and Chemokine (C-C motif) ligand 7 (CCL7)