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Fig. 7 | Immunity & Ageing

Fig. 7

From: Bifidobacterium bifidum and Lactobacillus paracasei alleviate sarcopenia and cognitive impairment in aged mice by regulating gut microbiota-mediated AKT, NF-κB, and FOXO3a signaling pathways

Fig. 7

Effects of Bb, Lp, and LB on the gut microbiota composition in aged mice. Effect on the microbiota composition at the phylum (a) or family levels (b). Effects on OTUs (α-diversity, c) and β-diversity (principal coordinate analysis [PCoA] plot based on BrayCurtis) (d). The relationship between gut microbiota and total muscle weight (e), GA muscle weight (f), TNF-α to IL-10 expression ration (g), IL-6 to IL-10 expression ratio (h), MuRF1 expression (i), or MyHC expression (j) in the GA, assessed by Spearman coefficient test. Bb, Lp, and LB (1 × 109 CFU/mouse/day) and Cr (75 mg/kg) were orally gavaged once a day (6 days in one week) for 8 weeks. Data are indicated as mean ± SD (n = 6). *p < 0.05 vs. Vh/Ag

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Immunity & Ageing

ISSN: 1742-4933

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