Skip to main content
Fig. 1 | Immunity & Ageing

Fig. 1

From: Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway

Fig. 1

CircZBTB46 is highly expressed in CAD, and circZBTB46 knockdown attenuates the progression of atherosclerosis. (A-B) Fluorescence in situ hybridization (FISH) was used to show the location and expression of circZBTB46 in human atherosclerotic plaques. Fluorescence intensity was measured using ImageJ software and the mean fluorescence intensity was represented as mean ± SEM. (C) The schedule of atherosclerosis model establishment and AAV intervention. (D) The relative expression of circZBTB46 in the heart in the two groups. (E-F) Oil red O staining of the intact aortas and cross-sections of aortic roots. (G) HE staining of the aortic sinus in the AAV-sh-NC and AAV-sh-circZBTB46. (H) Masson staining of the aortic sinus in the two groups of mice after AAV intervention. (I) α-SMA, (J) CD31, and (K) F4/80 staining in the aortic sinus in the AAV-sh-NC and AAV-sh-circZBTB46 groups. *p < 0.05, **p < 0.01, ***p < 0.001

Back to article page

Immunity & Ageing

ISSN: 1742-4933

Contact us