Fig. 2
Comparison of senescence-associated secretory phenotype (SASP) proteins between subjects who spontaneously cleared HCV versus the control group: A All individuals, B Male individuals, C Female individuals. Statistics: Data were calculated by Generalized Linear Models (GLM) with a gamma distribution (log-link) adjusted by those clinical variables selected following a stepwise method from age, sex, IFN-λ4 genotype (rs12979860), and aspartate transaminase (AST) for A), and by sex, IFN-λ4 genotype (rs12979860), and aspartate transaminase (AST) for B) and C)(see Results Section). The q-values represent p-values corrected for multiple testing using the False Discovery Rate (FDR). Significant differences are shown in bold. Abbreviations: AMR, arithmetic mean ratio; aAMR, adjusted AMR; 95%CI, 95% of confidence interval; q, corrected level of significance; EGF, epidermal growth factor; GRO-alpha/KC, chemokine growth-regulated protein alpha; GM-CSF, granulocyte–macrophage colony-stimulating factor; IFN, interferon; IL, interleukin; MCP-1, C–C motif chemokine ligand 2; RANTES, C–C motif chemokine ligand 5; SDF-1alpha, stromal cell-derived factor 1alpha; FGF-2, fibroblast growth factor 2; HGF, hepatocyte growth factor; Beta-NGF, nerve growth factor β; PLGF-1, placental growth factor; SCF, skp, cullin, F-box containing complex; TNF, tumoral necrosis factor