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Fig. 4 | Immunity & Ageing

Fig. 4

From: Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions

Fig. 4

The effect of anti-VCAM-1 antibody and VLA4 inhibitor on subretinal fibrosis. A Schematic diagram showing experimental design. Mice were treated with intravitreal injection (IVI) of anti-VCAM-1 mAb, VLA-4 inhibitor or vehicle immediately after the second laser. Eyes were collected on day 10 for immunofluorescence staining. B Representative images of RPE/choroid flatmounts stained for collagen-1 (COL-1); C quantitative analysis of COL-1+ lesion areas. D Representative images of COL-1 staining of RPE/choroid flatmounts; E quantification of COL-1+ lesion areas. Graphs represent mean ± SD, n = 28 lesions per group from 7 eyes, **P < 0.01, unpaired t test

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Immunity & Ageing

ISSN: 1742-4933

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