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Table 2 The aqueous levels of ICAM-1, VCAM-1, CD44, CD62L and CD62P in nAMD patients with and without macular fibrosis (Mean ± SD)

From: Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions

Variables

Controls

Fibrosis absent

Fibrosis present

P value

P value

P value

P value

P value

    

Fibrosis absent

Fibrosis absent vs

bonferroni

Fibrosis absent vs

adjust for

(Lg pg/ml)

n = 24

n = 24

n = 24

vs presenta

present vs Conb

post hoc tests

present vs Con||

Gender||

ICAM-1

2.78 ± 0.30

3.15 ± 0.27

3.23 ± 0.34

0.413

 < 0.001

 < 0.001c

 < 0.001

 < 0.001c

      

 < 0.001d

 

 < 0.001d

VCAM-1

3.79 ± 0.27

3.97 ± 0.44

4.21 ± 0.45

0.064

0.002

0.358c

0.001

0.097c

      

0.001d

 

0.001d

CD44

2.17 ± 0.21

2.46 ± 0.09

2.50 ± 0.32

0.560

 < 0.001

 < 0.001c

 < 0.001

 < 0.001c

      

 < 0.001d

 

0.001d

CD62L

3.16 ± 0.28

3.66 ± 0.08

3.72 ± 0.19

0.188

 < 0.001

 < 0.001c

 < 0.001

 < 0.001c

      

 < 0.001d

 

 < 0.001d

CD62P

2.08 ± 0.26

2.03 ± 0.36

2.10 ± 0.35

0.451

0.699

/

0.918

/

  1. The data were log-transformed to obtain normal distribution
  2. aIndependent samples t-test
  3. bOne-way ANOVA
  4. cControls vs Fibrosis absent
  5. dControls vs fibrosis present
  6. ||Adjusted for gender with multivariable linear regression analysis