Fig. 5

Body mass index (BMI) has an important impact on levels of inflammageing markers and plays a role as a confounder in the association between frailty and inflammageing markers. In A, we show the associations of 29 markers with BMI in the VITAL cohort. In B, we show associations of 29 markers with frailty measures corrected for BMI, age and sex. The inflammageing markers are divided in groups A, B, C, and D based on their trajectory with age, see Fig. 2. Statistical significance of the Spearman’s correlation coefficient is indicated with *: p < 0.05, **: p < 0.01, ***: p < 0.001, ***: p < 0.0001