Table 1 Characteristics of VITAL cohort participants included in this study

N

317

63

95

159

Age median (IQR)

65 (54–75)

35 (29–42)

58 (55–61)

75 (69–81)

Sex % female

54

67 ^a

59

47

BMI kg/m², median (IQR)

24.6 (22.4–27.5)

24.0 ^a b (21.5–25.5)

24.0 (21.8–26.5)

25.3 (23.4–28.6)

CMV %positive / %negative

48/51

42/57

51/47

50/48

EBV %positive / %negative

83/14

76/18

87/13

83/13

Smoking, %smoking > 4 cigarettes/week

3.7

1.6

3.2

5.0

Frailty index median (IQR)

0.13 (0.08–0.20)

0.06 ^{a b} (0.03–0.10)

0.10 ^c (0.06–0.14)

0.18 (0.13–0.26)

EQ-5D-3L median (IQR)

1 (0.81–1)

1 ^a (0.84–1)

1 ^c (0.84–1)

0.84 (0.81–1)

SF-36 PF median (IQR)

95 (80–100)

100 ^{a b} (95–100)

95 ^c (90–100)

85 (65–95)

SF-36 HG median (IQR)

70 (60–80)

75 ^a (70–85)

75 ^c (65–85)

65 (55–75)

Health rating median (IQR)

8.0 (7.0–8.5)

8.0 (7.5–9.0)

8.0 (7.5–9.0)

8.0 (7.0–8.5)

Number of medications median (IQR)

2 (0–4)

0 ^a (0–1)

1 ^c (0–2)

4 (2–6)