Table 2 Levels of inflammageing markers differ between age groups

N

317

63

95

159

 Group a

 IL-6

pg/mL

0.89 (0.46–1.37)

0.40 (0.22–0.84)

0.69 (0.43–1.12)

1.10 (0.72–1.74)

 Elastase

ng/mL

208 (153–296)

175 (128–220)

195 (154–271)

228 (166–338)

 sCD163

ng/mL

745 (518–1134)

529 (381–547)

681 (530–1039)

906 (627–1244)

 CXCL10 (IP-10)

pg/mL

24.7 (18.8–31.7)

18.8 (14.7–23.2)

21.2 (17.5–28.5)

29.1 (22.1–35.4)

 YKL-40

ng/mL

37.6 (26.0–67.7)

24.3 (19.7–31.2)

30.3 (22.0–42.9)

58.2 (35.8–93.6)

 Neopterin

nmol/L

8.47 (5.74–11.33)

5.78 (4.11–8.01)

7.65 (5.64–9.72)

10.45 (7.13–13.95)

Group b

 CCL2

pg/mL

402 (317–498)

335 (290–416)

413 (319–519)

417 (339–523)

 IL-8

pg/mL

20.5 (14.8–34.1)

14.9 (11.5–21.4)

20.5 (15.3–42.6)

22.3 (16.4–35.4)

 sIL-6R

ng/mL

46.9 (41.3–52.9)

42.8 (37.3–49.6)

47.1 (41.3–52.9)

48.4 (42.4–53.8)

 iFABP2

pg/mL

1138 (843–1644)

908 (660–1233)

1113 (863–1507)

1235 (932–1839)

 sGP130

ng/mL

143 (131–157)

134 (120–145)

143 (130–158)

147 (136–158)

Group c

 PR3

ng/mL

32.4 (24.5–46.8)

27.9 (22.6–38.6)

28.7 (19.9–42.9)

37.9 (26.4–52.7)

 CRP

mg/L

1.19 (0.55–2.82)

0.75 (0.23–1.89)

1.00 (0.45–2.29)

1.62 (0.68–3.31)

 sCD14

ng/mL

1446 (1252–1645)

1327 (1129–1533)

1418 (1229–1573)

1661 (1135–2254)

 Angiopoietin-2

pg/mL

2023 (1593–2742)

1787 (1268–2545)

1909 (1545–2319)

2233 (1749–3000)

 sCD25

pg/mL

522 (427–653)

467 (381–547)

478 (388–61)

595 (488–718)

 IL-1RA

pg/mL

855 (670–1106)

708 (567–975)

770 (651–992)

936 (779–1245)

 IFN-γ

pg/mL

0.04 (0.03–0.07)

0.03 (0.02–0.04)

0.04 (0.02–0.06)

0.05 (0.03–0.08)

 SAA

ng/mL

135 (6–735)

45 (5–356)

67 (5–356)

259 (39–886)

Group d

 Calprotectin

ng/mL

1586 (1102–2310)

1538 (772–2084)

1661 (1135–2254)

1661 (1135–2254)

 C5a

ng/mL

21.3 (16–28.6)

19.5 (15.6–25.5)

19.6 (14.7–28.7)

22.7 (16.9–29.5)

 PTX-3

pg/mL

5519 (4103–7188)

5328 (3789–6988)

5402 (4032–6949)

5679 (4697–7278)

 Cathepsin G

ng/mL

6.62 (4.70–8.66)

6.48 (4.60–8.04)

6.10 (4.65–8.83)

7.20 (4.83–8.77)

 A1AT/elastase complex

µg/mL

56 (38–96)

55 (9–106)

73 (26–135)

52 (39–81)

 GM-CSF

pg/mL

0.17 (0.13–0.22)

0.17 (0.13–0.23)

0.17 (0.12–0.22)

0.18 (0.13–0.22)

 IL-1β

pg/mL

0.03 (0.01–0.-6)

0.02 (0.01–0.05)

0.04 (0.02–0.07)

0.03 (0.01–0.06)

 TNF-α

pg/mL

2.22 (1.87–2.68)

2.08 (1.72–2.52)

2.31 (1.81–2.68)

2.21 (1.81–2.68)

 IL-10

pg/mL

0.57 (0.42–0.83)

0.50 (0.38–0.68)

0.66 (0.45–0.86)

0.56 (0.40–0.84)

 IFN-α

pg/mL

0.01 (0.01–0.02)

0.01 (0.01–0.02)

0.01 (0.00–0.02)

0.01 (0.01–0.02)