Frailty is related to serum inflammageing markers: results from the VITAL study

Immunity & Ageing

Table 3 Multiple linear regression analysis of associations of the inflammageing markers and age

Dependent variable	Predicting variable	Final model of multiple linear regression B (95% CI)	Standardized B value	p value
Total participants (n = 292)¹
Frailty Index scores	Age	0.008 (0.006–0.010)	0.456	< 0.001
	CRP	0.097 (0.037–0.157)	0.169	0.002
	IL-1RA	0.225 (0.056–0.395)	0.140	0.009
Female participants (n = 157) ²
Frailty Index scores	Age	0.007 (0.005–0.010)	0.405	< 0.001
	IL-1RA	0.343 (0.159–0.527)	0.244	< 0.001
	IL-6	0.162 (0.049–0.275)	0.213	0.005
Male participants (n = 135) ³
Frailty Index scores	Age	0.008 (0.005–0.11)	0.406	< 0.001
	YKL-40	0.278 (0.126–0.430)	0.299	< 0.001
	PR3	-0.143 (-0.274–-0.012)	-0.153	0.033

All data, with the exception of age, were log-transformed. Biomarkers that were not normally distributed after log transformation were excluded (SAA, Cathepsin G, A1AT/Elastase, IL-1β, IFNα). Participants with missing data were excluded from the analysis (n = 40). Regression was performed with stepwise inclusion of variables, results of the most predictive models are shown
¹R² = 0.358, F(3,277) = 51.558, p < 0.001
²R² = 0.457, F(3,145) = 40.771, p < 0.001
³R² = 0.375, F(3,128) = 25.661, p < 0.001

ISSN: 1742-4933