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Fig. 3 | Immunity & Ageing

Fig. 3

From: Hindlimb unloading, a physiological model of microgravity, modifies the murine bone marrow IgM repertoire in a similar manner as aging but less strongly

Fig. 3

The IgM repertoire of HU and aged mice was different from that of the corresponding 3.5-month-old controls. A Dispersion indexes for unique VDJ associations in the bone marrow of control vs. HU and young vs. aged mice. B, C, D Dispersion indexes for IGHV (B), IGHD (C) and IGHJ (D) segment usage in the bone marrow of control vs. HU mice and young vs. aged mice. Data are shown as the means ± SDs of 4 groups, each comprising 5 mice (N = 4, n = 5). Statistically significant differences were found using one-way ANOVA followed by a Tukey–Kramer post hoc test. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; n.s., nonsignificant

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Immunity & Ageing

ISSN: 1742-4933

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