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Fig. 5 | Immunity & Ageing

Fig. 5

From: Hindlimb unloading, a physiological model of microgravity, modifies the murine bone marrow IgM repertoire in a similar manner as aging but less strongly

Fig. 5

Impact of HU and aging on heavy-chain CDR3s. A, B Frequencies of sequences according to CDR3 length in control vs. HU (A) and young vs. aged (B) mice. C, D Analyses of the amino acid composition of the most frequent CDR3s (11 to 14 amino acids) in control vs. HU (C) and young vs. aged (D) mice. Dispersion indexes for CDR3 amino acid composition in HU and aged mice were compared to the corresponding controls aged 3.5 months. Data are shown as the means ± SDs of 4 groups, each comprising 5 mice (N = 4, n = 5). Statistically significant differences were found using Mann–Whitney or unpaired t tests. *p ≤ 0.05; t indicates a trend

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Immunity & Ageing

ISSN: 1742-4933

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