Fig. 2
From: The role of NLRP3 inflammasome in aging and age-related diseases
Two-step activation of NLRP3 inflammasome at the molecular level. ASC, apoptosis-associated speck-like protein; DAMP, damage-associated molecular pattern; IL-1β, interleukin-1β; NLPR3, NOD-like receptor protein 3; PAMP, pathogen-associated molecular pattern; pro-IL-1β, pro-interleukin-1β; TLR4, Toll-like receptor 4