Fig. 5

NLRP3 inflammasome in the progression of certain other aging-related diseases. BCP, basic calcium phosphate; caspase-1, cysteine-aspartic protease 1; CRP, C-reactive protein; DAMPs, damage-associated molecular patterns; IAPP, islet amyloid polypeptide; IL, interleukin; LPS, lipopolysaccharides; pro-IL-1β, pro-interleukin-1β; PDTC, pyrrolidine dithiocarbamate; PVN, paraventricular nucleus; SHR, spontaneously hypertensive rats; T2DM, type 2 diabetes mellitus; TLR4, toll-like receptor 4; TLRs, toll-like receptors; VEGF-A, vascular endothelial growth factor A; VSMCs, vascular smooth muscle cells