Fig. 1

Gene discovery diagrams and Hallmark gene sets and KEGG pathways enriched by analyzed genes in independent Yale Cohort. A, B Gene discovery involved the analysis of 26,133 total genes based on publicly available databases that included AD (GSE140829, and GSE63060 and GSE63061 gene expression microarray datasets from a combined total of 428 patients with AD and 554 cognitively normal subjects, selected genes were those differentially expressed in ≥ 2 of these datasets) and memory (GSE127711) gene expression microarray datasets as well as the Molecular Signatures Database (MSigDB). This resulted in the discovery of 29 candidate genes (i.e., putative AD genes) which could be possibly altered in their expression levels in AD. Of the 29 genes, 9 were IL-7 receptor alpha low (IL-7Rα^low) aging genes (n = 231). Gene discovery diagram C Showing the distinct characteristics of the analyzed gene categories. In addition to the genes identified by a systematic search of publicly available data, top IL-7Rα^low aging genes (i.e., IL-7Rα^low aging genes most associated with chronological age) were also studied. Hallmark gene sets and KEGG pathways D Identified by gene set enrichment analysis (GSEA) of the 40 analyzed genes