Fig. 2

A set of genes associated with IL-7 receptor alpha (low) effector memory CD8⁺ T cells and Alzheimer’s disease (AD) is differentially expressed in peripheral blood of patients with AD. Reverse transcription qPCR (RT-qPCR) analysis showing differentially expressed genes in peripheral blood of cognitively normal (CN) and AD participants with mild cognitive impairment (MCI) or dementia. A Top IL-7 receptor alpha low (IL-7Rα^low) effector memory (EM) CD8⁺ T cell-associated aging genes. B PADI4, an IL-7Rα^low aging gene found to be upregulated in 3 AD transcriptomic datasets. C Genes associated with AD transcriptomic datasets but not in the IL-7Rα^low EM CD8⁺ T cell associated aging gene signature. P values were obtained by ANOVA and adjusted during post-hoc multiple comparison testing using the Šidák correction