Fig. 5

Clusters in dementia group associated with higher IL-7 receptor alpha (low) aging gene expression exhibit higher cognitive functioning according to comprehensive neuropsychological testing. A The Montreal Cognitive Assessment (MoCA) scores, Clinical Dementia Rating scale sum of boxes (CDRsob) scores, and Global Cognition composite scores of Dementia Cluster 1 compared to Dementia Clusters 2 & 3 combined. Dementia Clusters 1, 2 and 3 were identified based on PCA analysis in Fig. 4A. B Neuropsychological testing Z-scores of individual cognitive domains plotted according to dementia clusters. P values were obtained by unpaired t-test. C Unbiased hierarchal clustering heatmap of dementia participants’ Spearman’s rho coefficients (reflecting correlations between neuropsychological testing scores and all analyzed gene expression levels) were impartially categorized according to cognitive domain