Fig. 6
From: IL-17A promotes the progression of Alzheimer’s disease in APP/PS1 mice
IL-17A promoted Aβ generation in HT22 cells. A Expression of APP proteins in HT22 cells that were transfected with APP overexpression plasmid and subsequently incubated with LPS and/or IL-17A for 24 h. B Aβ1-42 levels in the culture medium of HT22 cells that were transfected with APP-overexpressing plasmids and subsequently incubated with LPS and/or IL-17A for 24 h. C Aβ1-40 levels in the culture medium of HT22 cells that were transfected with APP-overexpressing plasmids and subsequently incubated with LPS and/or IL-17A for 24 h. D Aβ1-42 and Aβ1-40 levels in the culture medium of HT22 cells that were transfected with APP-overexpressing plasmids and subsequently incubated with LPS and IL-17A or BV2 for 24 h. The values are expressed as the mean ± standard deviation (****P < 0.0001, ***P < 0.001, **P < 0.01, and *P < 0.05). The data are representative of at least three independent experiments