Fig. 7
From: IL-17A promotes the progression of Alzheimer’s disease in APP/PS1 mice
Diagram showing the regulatory mechanism of IL-17A in AD. The level of the cytokine IL-17A that was secreted by peripheral immune cells increased, and the BBB was damaged. Peripheral IL-17A may promote the production of TNF-α through the TLR4/NF-κB signalling pathway, leading to an increase in Aβ production, reducing the phagocytic ability of microglia, weakening the clearance of Aβ, and exacerbating the progression of AD