Fig. 1

Immune phenotype variation between cancer patients and healthy populations. The peripheral blood mononuclear cells (PBMC) of cancer patients (n = 1375) and healthy control (n = 275) were detected by flow cytometry. (A-E) The percentage of CD19⁺ B cells, CD16⁺ CD56⁺ NK cells, CD3⁺CD45⁺ cells, CD3⁺CD4⁺ Th cells, and CD3⁺CD8⁺ CTL in the two groups. (F) The ratio of CD4⁺/CD8⁺ T cells. (G-J) The percentage of PD-1⁺CD45⁺ cells, PD-1⁺CD3⁺ T cells, PD-1⁺ CD3⁺CD4⁺ Th cells, and PD-1⁺CD3⁺CD8⁺ CTL. Data were shown as mean ± SEM. Statistic differences between the two groups were detected by unpaired t-tests and were indicated as follows: *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001