Fig. 4

The PD-1⁺ T cells and its variation in cancer patients. (A-D) The correlation between the percentage of PD-1⁺CD45⁺ cells, PD-1⁺CD3⁺ T cells, PD-1⁺CD3⁺CD4⁺ Th cells, PD-1⁺CD3⁺CD8⁺ CTL and age in cancer patients. The Pearson correlation coefficient was computed to evaluate correlations between two parameters. (E-H) The percentage of PD-1⁺CD45⁺ cells, PD-1⁺CD3⁺ T cells, PD-1⁺CD3⁺CD4⁺ Th cells, and PD-1⁺CD3⁺CD8⁺ CTL in male (n = 770) and female (n = 605) cancer patients. (I-L) The percentage of PD-1⁺CD45⁺ cells, PD-1⁺CD3⁺ T cells, PD-1⁺CD3⁺CD4⁺ Th cells, and PD-1⁺CD3⁺CD8⁺ CTL among early, middle, and late stage. Data were shown as mean ± SEM. Statistic differences between two groups were detected by unpaired t-tests. As for data containing more than two groups, they were compared by one-way ANOVA test followed by the Turkey test. P values were indicated as follows: *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001