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Fig. 5 | Immunity & Ageing

Fig. 5

From: Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus

Fig. 5

Senescent mesenchymal cell count increased in the strongly immune cell–infiltrated regions. (a) Representative images of immunohistochemical staining for p21, PDGFRα, and CD45 in the subepithelial layer of oral mucosa sections from patients with oral lichen planus (OLP) and control groups. CD45-positive immune cell infiltration was graded as weak-moderate (≤ 40% area of CD45-positivity) and strong (> 40% area of CD45-positivity). (b) Quantification of p21 positive cells in control and patients with OLP. Data are presented as the mean and standard error (SE) with dot plots. The circular dot plots represent females, and the triangles represent males. P-values were determined using Tukey’s method for one-way analysis of variance (**p < 0.001)

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Immunity & Ageing

ISSN: 1742-4933

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