Fig. 3
From: Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions
SNX27 partial depletion does not alter naïve, memory and effector T cell subsets. A-I Cells from SNX27fl/fl and CD4-Cre-SNX27fl/+ mice were extracted from blood, bone marrow, and spleen. Graphs show the percentage of naïve (CD44− CD62L+) (A, D, G), central memory (CD44+ CD62L+) (B, E, H), and effector (CD44+ CD62−) (C, F, I) cells among CD4+ and CD8+ T cell populations in (A-C) blood samples, (D-F) bone marrow cells, and (G-I) splenocytes. Gating strategies are shown in Suppl Fig. 5. Data shown as mean ± SEM; two-way ANOVA with Bonferroni post-test was used for multiple comparisons; ns p > 0.05; n = 11 mice in (A-F) and n = 9 mice in (G-I). SNX Sorting nexin, SEM Standard error of the mean