Fig. 1
From: sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence
Shedding of soluble CD163. Various inflammatory signals induce shedding of sCD163 in vitro. Shedding of sCD163 can be induced by TLR4 activation or FcγR-crosslinking mediated by ADAM17/TACE. Half-life of sCD163 is longer than that of TNF-α. FcγR, Fc-gamma receptors; LPS, Lipopolysaccharides; TACE/ADAM17, Tumor necrosis factor α-converting enzyme; TLR, Toll-like receptors; TNF, Tumor necrosis factor. Reprinted with permission from Reference: Møller, H. J. 2012. Soluble CD163. Scandinavian journal of clinical and laboratory investigation, 72, 1–13