Fig. 2
From: sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence
Interaction between APC receptor (CD80 and CD86) with T cell receptor (CD28 and CTLA-4). (A) Both CD80 and CD86 can bind to CD28 or CTLA-4. (B) Binding of CD80 or CD86 to CD28 will activate T cells also shedding of CD28 (become sCD28). (C) Binding of sCD80 to CD28 will activate T cells. (D) Binding of CD80 or CD86 to CTLA-4 will suppress T cells also shedding of CTLA-4 (become sCTLA-4). (E) Binding of sCD80 to CTLA-4 will suppress T cells. (F) If CD80 or CD86 bind to either sCD28 or sCTLA-4, T cells will have no response and become anergy