Fig. 7
From: Accelerated immune ageing is associated with COVID-19 disease severity
Immunological ageing score (IMM-AGE) and transcriptome signatures in severe COVID-19 convalescent patients. A IMM-AGE scores calculated by the pseudotime algorithm23 in healthy age and sex-matched controls (n = 39) and mild (n = 15), moderate (n = 33) and severe (n = 42) COVID-19 survivors 3–5 months post-infection. Statistical analysis by two-sided Mann–Whitney non-parametric test. If not indicated, p value is not significant. B (B) A heatmap showing the relative expression levels of a selection of significantly differentially expressed genes between the healthy control and severe COVID-19 groups. The gene IDs can be seen on the X axis. The figure legend colour corresponds to the relative expression levels of a given gene within a group. C An map plot showing the relationships between the pathways associated with the set of significantly differentially expressed genes between healthy control participants and survivors of severe covid-19 infection. Node size denotes the number of genes associated with a specific pathway, with increasing size reflecting a greater number, and colour reflects the adjust p-valuealue