Inflammatory markers and physical frailty: towards clinical application

Pan, Yiming; Ma, Lina

doi:10.1186/s12979-023-00410-3

Immunity & Ageing

Table 2 Comparison of inflammatory markers for frailty

From: Inflammatory markers and physical frailty: towards clinical application

Studies	Design	Population		Inflammation parameter
Studies	Design	Population		TNF-α	TNFR1	TNFR2	genotype	IL-6	CRP
Schaap 2009	Longitudinal (5y)	≥ 70y, n = 2177		+	+	+	N/S	-	-
Aguirre 2014	Cross-sectional	≥ 65y, n = 107		N/S	+	N/S	N/S	-	-
Arts 2015	Cross-sectional	≥ 60y, n = 366		N/S	N/S	N/S	N/S	-	-
Liu 2016	Cross-sectional	> 60y, n = 1919		N/S	N/S	-	N/S	+	-
Mekli 2016	Cross-sectional	≥ 50y, n = 3160		N/S	N/S	N/S	+	N/S	N/S
Tay 2016	Longitudinal (1y)	≥ 65y, n = 99		+	N/S	N/S	N/S	-	N/S
Van Epps 2016	Cross-sectional	≥ 60y, n = 117		N/S	+	+	N/S	+	-
Langmann 2017	Longitudinal (2y)	≥ 65y, n = 178	Baseline	N/S	+	+	N/S	+	+
Langmann 2017	Longitudinal (2y)	≥ 65y, n = 178	1y Follow-up	N/S	-	-	N/S	+	+
Marcos-Pérez 2018	Cross-sectional	≥ 65y, n = 259		+	N/S	+	N/S	+	+
Yang 2018	Cross-sectional	≥ 60y, n = 435		N/S	N/S	N/S	N/S	-	-
Navarro-Martínez 2019	Cross-sectional	≥ 50y, n = 46		-	N/S	N/S	N/S	+	+
Prince 2019	Cross-sectional	≥ 30y, n = 68		N/S	N/S	N/S	+	N/S	N/S
Buigues 2020	Longitudinal (1y)	≥ 50y, n = 39	Baseline	-	N/S	N/S	N/S	+	+
Buigues 2020	Longitudinal (1y)	≥ 50y, n = 39	1y Follow-up	-	N/S	N/S	N/S	+	-
Furtado 2020	Cross-sectional	≥ 75y, n = 358		+	N/S	N/S	N/S	+	-
Castellana 2021	Longitudinal (6y)	≥ 65y, n = 1929		+	N/S	N/S	N/S	+	-
Castro-Herrera 2021	Cross-sectional	≥ 65y, n = 184		-	N/S	-	N/S	-	+
McKechnie 2021	Longitudinal (3y)	≥ 70y, n = 981		N/S	N/S	N/S	N/S	+	-
Teixeira-Gomes 2021	Cross-sectional	≥ 65y, n = 291		N/S	N/S	N/S	N/S	+	+
McKechnie 2022	Cross-sectional	≥ 70y, n = 1399		N/S	N/S	N/S	N/S	+	+
Pansarasa 2022	Cross-sectional	≥ 75y, n = 219		+	N/S	N/S	N/S	+	+
Samson 2022	Longitudinal (20y)	≥ 65y, n = 144	Baseline	N/S	N/S	N/S	N/S	+	+
Samson 2022	Longitudinal (20y)	≥ 65y, n = 144	5y Follow-up	N/S	N/S	N/S	N/S	-	-

Abbreviations: IL, interleukin; TNF, tumor necrosis factor; CRP, C-reactive protein

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