Fig. 1
From: Monocyte alteration in elderly hip fracture healing: monocyte promising role in bone regeneration
Human CD14 + + CD16- classical cM leave the bone marrow in a CC-chemokine receptor 2 (CCR2)-after fracture. During inflammation, classical and intermediate. MCs are tethered and invade tissue by interaction of complementary pair CCR2/CCL2(MCP1) or/and CCR5/CCL5(RANTES) in a VLA1/VCAM1 dependent manner. MCs then mature to 746 M1Mϕ in tissue and present self-antigen via MHC-I/II to TCR leading to TC activation. Non- classical MCs patrol the vessel wall and invade by interaction of complementary pair of 748 CX3CR1/CCL3 via LAF/ICAM1-dependent manner