Table 2 Differences in various activation markers according to pre-frailty. SD, standard deviation; IQR, interquartile range. Differences were evaluated using ANOVA
From: Immune profiles of pre-frail people living with HIV-1: a prospective longitudinal study
| Â | Fried score | Difference between the 3 groups (p) | ||
|---|---|---|---|---|
0 | 1 | 2 | ||
% CD4 T cells (mean ± SD) | 50.1 ± 10.4 | 45.6 ± 9.8 | 34.4 ± 16.8 | 0.008 |
% CD8 T cells (mean ± SD) | 45.2 ± 9.9 | 47.5 ± 7.4 | 60.1 ± 17.9 | 0.009 |
% NK cells CD56- (mean ± SD) | 15.5 ± 11.0 | 25.4 ± 21.4 | 13.7 ± 5.3 | 0.106 |
% effector memory CD8 T cells (mean ± SD) | 9.5 ± 7.0 | 14.9 ± 10.9 | 8.4 ± 6.1 | 0.126 |
tPA, ng/mL (mean ± SD) | 14.7 ± 6.7 | 11.2 ± 3.3 | 14.0 ± 4.7 | 0.223 |
% naïve CD8 T cells (median [IQR]) | 29.7 [19.8–42.2] | 23.2 [19.0-35.2] | 22.6 [21.6–25.6] | 0.233 |
% NK cells CD57+ (mean ± SD) | 52.4 ± 18.1 | 41.8 ± 22.2 | 43.4 ± 24.3 | 0.234 |
% CD4 T cells CD38+ (mean ± SD) | 54.1 ± 10.8 | 60.7 ± 14.2 | 57.3 ± 10.7 | 0.282 |
sEPCR µg/mL (median [IQR]) | 117.2 [75.9-170.5] | 103.1 [81.5-137.1] | 95.4 [83.6-128.9] | 0.338 |
sTNFRI, ng/mL (median [IQR]) | 1.30 [1.20–1.50] | 1.60 [1.20–1.90] | 1.35 [1.20–1.57] | 0.368 |
% CD8 T cells HLA-DR + CD38+ (mean ± SD) | 35.0 ± 16.2 | 42.1 ± 9.9 | 40.2 ± 20.0 | 0.375 |
% CD8 T cells PD-1+ (mean ± SD) | 47.5 ± 23.2 | 38.7 ± 22.8 | 53.3 ± 24.4 | 0.394 |
% CD4 T cells HLA-DR + CD38+ (mean ± SD) | 7.6 ± 4.8 | 9.2 ± 6.6 | 10.2 ± 6.3 | 0.424 |
sCD163, pg/mL (mean ± SD) | 576.0 ± 213.5 | 668.5 ± 318.8 | 714.3 ± 496.7 | 0.465 |