Table 2 Proportions of activated, regulatory, and inhibitory T-cell subsets. Group comparisons were performed by One-Way (ANOVA) or Kruskal-Wallis

CD3⁺CD4⁺

CD38⁺

27.8 (6.8–56.7)

8.36 (1.37–14.1)^A

6.21 (1.3–14.1)^A

0.0001

HLA-DR⁺

1.28 (0.5–4.9)

1.48 (0.4–7.7)

1.37 (0.5–38.8)

0.9285

CD69⁺

6.55 (0.1–77.5)

3.86 (1.5–7.3)

4.87 (1.1–40.2)

0.1527

CD25⁺

26.50 (17.5–51.9)

38.00 (26.4–56.1) ^A

37.25 (7.0–56.5)

0.0455

CD38⁺HLA-DR⁺

3.17 (1.5–11.1)

2.47 (0.2–7.7)

2.42 (0.1–10.7)

0.6388

CD25⁺CD69⁺

1.45 (0.0–13.9)

1.17 (0.3–12.2)

1.71 (0.3–29.0)

0.3861

CD25^LOWCD127+

9.13 (4.8–29.8)

22.30 (12.1–61.6) ^A

19.65 (0.1–29.8)

0.0340

CD25^-CD127⁺

83.0 (12.2–91.2)

65.60 (27.2–78.8)

63.10 (35.2–82.8)

0.7142

CD25^-CD127^-

2.40 (0.4–13.5)

1.31 (0.0–18.5)

4.41 (0.0–48.5)

0.4452

CD25⁺CD127^low/neg

0.23 (0.0–43.5)

3.33 (0.0–39.10) ^A

4.89 (0.0–49.5) ^A

0.0023

PD-1⁺

4.74 (0.2–15.4)

7.37 (1.8–33.0)

8.34 (2.2–60.7)

0.1320

TIM-3⁺

1.13 (0.0–29.2)

1.53 (0.5–32.2)

2.49 (0.3–66.7)

0.6394

LAG-3⁺

0.20 (0.0–1.0)

0.50 (0.0–12.5) ^A

0.60 (0.7–66.7) ^A

0.0430

CTLA-4⁺

1.70 (0.2–60.8)

0.55 (0.0–2.8)

0.69 (0.1–66.7)

0.0580

CD3⁺CD8⁺

CD38⁺

14.30 (11.1–52.0)

9.85 (0.5–33.6) ^A

7.93 (0.3–33.1) ^A

0.0136

HLA-DR⁺

3.15 (0.0–17.9)

3.11 (0.2–13.4)

3.24 (0.8–38.6)

0.7557

CD69⁺

5.40 (0.3–28.2)

7.83 (3.9–23.4)

5.40 (0.3–28.2)

0.1203

CD25⁺

19.80 (12.3–47.8)

26.80 (15.3–50.4)

28.55 (8.4–79.9)

0.2889

CD38⁺HLA-DR⁺

3.63 (0.5–12.1)

2.20 (0.1–14.1)

1.51 (0.3–18.0)

0.2910

CD38⁺GZB⁺

11.60 (2.1–35.2)

7.79 (1.2–72.5)

9.28 (1.1–39.6) ^A

0.0326

CD38⁺HLA-DR⁺GZB⁺

31.60 (5.1–77.6)

28.20 (0.0–98.5)

21.10 (2.3–80.0)

0.3230

CD25⁺CD69⁺

3.39 (0.0–10.1)

1.81 (0.3–6.6)

2.54 (0.4–33.7)

0.2578

CD25^LOWCD127+

2.29 (0.2–7.1)

9.40 (4.5–36.5) ^A

9.63 (2.3–38.3) ^A

0.0008

CD25^-CD127⁺

7.55 (1.1–14.2)

34.20 (8.9–59.3) ^A

32.00 (9.6–58.1) ^A

0.0001

CD25^-CD127^-

72.70 (26.4–92.1)

4.1 (0.0–17.9)

4.10 (0.0–17.9) ^A

0.0182

CD25⁺CD127^low/neg

9.81 (3.4–55.5)

4.64 (1.0–20.3) ^A

4.48 (0.0–20.2) ^A

0.0024

PD-1⁺

1.05 (0.1–21.7)

1.97 (0.1–55.2)

2.16 (0.3–87.0)

0.8971

TIM-3⁺

4.17 (0.1–71.2)

1.79 (0.3–22.7)

2.61 (0.2–31.0)

0.4060

LAG-3⁺

0.28 (0.0–2.9)

0.68 (0.5–7.4)

0.46 (0.0–20.7)

0.2748

CTLA-4⁺

0.60 (0.0–28.6)

0.35 (0.0–2.84)

0.63 (0.0–27.60)

0.1349