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  1. Content type: Review

    Aging is associated with a decline in immune function (immunosenescence), a situation known to correlate with increased incidence of cancer, infectious and degenerative diseases. Innate, cellular and humoral i...

    Authors: V Srinivasan, GJM Maestroni, DP Cardinali, AI Esquifino, SR Pandi Perumal and SC Miller

    Citation: Immunity & Ageing 2005 2:17

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  2. Content type: Commentary

    The problems associated with the ageing immune system and vaccination were discussed recently at an international workshop at the Jenner Institute for Vaccine Research, Compton, UK, 6–7 October, 2005. This is ...

    Authors: Graham Pawelec

    Citation: Immunity & Ageing 2005 2:16

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  3. Content type: Short report

    Osteoporosis is a condition characterized by low bone mass and increased bone fragility, putting patients at risk of fractures, which are major causes of morbidity substantially in older people. Osteoporosis i...

    Authors: Lia Ginaldi, Maria Cristina Di Benedetto and Massimo De Martinis

    Citation: Immunity & Ageing 2005 2:14

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  4. Content type: Research

    There is strong evidence that an individual's genetic background is an important predisposing factor to longevity. In the present study we analysed the frequency of HLA class I, class II, as well as the TNF-α ...

    Authors: Elena Soto-Vega, Yvonne Richaud-Patin and Luis Llorente

    Citation: Immunity & Ageing 2005 2:13

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  5. Content type: Review

    Human aging is associated with progressive decline in immune functions, increased frequency of infections. Among immune functions, a decline in T cell functions during aging predominates. In this review, we wi...

    Authors: Sudhir Gupta, Houfen Su, Ruifen Bi, Sudhanshu Agrawal and Sastry Gollapudi

    Citation: Immunity & Ageing 2005 2:12

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  6. Content type: Research

    A common feature of Alzheimer's disease (AD) pathology is the abundance of activated microglia in neuritic plaques containing amyloid-beta protein (Aβ) and associated molecules including heparan sulfate proteo...

    Authors: Simona Bussini, Lucia Meda, Elio Scarpini, Emilio Clementi, Giancarlo Conti, Marco Tiriticco, Nereo Bresolin and Pierluigi Baron

    Citation: Immunity & Ageing 2005 2:11

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  7. Content type: Research

    Streptococcus pneumoniae is a serious worldwide pathogen and the focus of numerous vaccine development projects. Currently the most widely accepted surrogate marker for evaluating the efficacy of a given vaccine ...

    Authors: Kris Kolibab, S Louise Smithson, Anne K Shriner, Sadik Khuder, Sandra Romero-Steiner, George M Carlone and MA Julie Westerink

    Citation: Immunity & Ageing 2005 2:10

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  8. Content type: Research

    Concerning allergic diseases, the incidence of allergic symptoms, as well as their severity, seems to decrease with age. The decline of onset of allergic symptoms observed in ageing might result from a decreas...

    Authors: Anja Mediaty and Karsten Neuber

    Citation: Immunity & Ageing 2005 2:9

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  9. Content type: Review

    The process of maintaining life for the individual is a constant struggle to preserve his/her integrity. This can come at a price when immunity is involved, namely systemic inflammation. Inflammation is not pe...

    Authors: Federico Licastro, Giuseppina Candore, Domenico Lio, Elisa Porcellini, Giuseppina Colonna-Romano, Claudio Franceschi and Calogero Caruso

    Citation: Immunity & Ageing 2005 2:8

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  10. Content type: Review

    Roy Walford died on April 27, 2004, at the age of 79. His contributions to gerontological research in such diverse areas as caloric restriction, genetics of lifespan, immunosenescence, DNA repair and replicati...

    Authors: Rita B Effros

    Citation: Immunity & Ageing 2005 2:7

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  11. Content type: Research

    Neutrophils represent the first line of defence against aggressions. The programmed death of neutrophils is delayed by pro-inflammatory stimuli to ensure a proper resolution of the inflammation in time and pla...

    Authors: Anis Larbi, Nadine Douziech, Carl Fortin, Annie Linteau, Gilles Dupuis and Tamas Fulop Jr

    Citation: Immunity & Ageing 2005 2:6

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  12. Content type: Commentary

    The problems associated with the ageing immune system coupled with possible solutions were discussed recently at the British Society for Immunology Annual Congress in Harrogate in December 2004. The session "A...

    Authors: Richard Aspinall

    Citation: Immunity & Ageing 2005 2:5

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  13. Content type: Research

    Down's syndrome (DS) is characterized by several immunological defects, especially regarding T cell compartment. DS is considered the best example of accelerated ageing in humans. Direct observations of the th...

    Authors: Nicole Prada, Milena Nasi, Leonarda Troiano, Erika Roat, Marcello Pinti, Elisa Nemes, Enrico Lugli, Roberta Ferraresi, Luigi Ciacci, Davide Bertoni, Ornella Biagioni, Milena Gibertoni, Cristina Cornia, Liviana Meschiari, Elisabetta Gramazio, Mauro Mariotti…

    Citation: Immunity & Ageing 2005 2:4

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  14. Content type: Research

    In a previous study we demonstrated the existence of numerical and functional alterations of γδ T cells in healthy elderly. Recently, we analysed the involvement of γδ T lymphocytes in malignant melanoma, desc...

    Authors: Francesca Re, Alessia Donnini, Beatrice Bartozzi, Giovanni Bernardini and Mauro Provinciali

    Citation: Immunity & Ageing 2005 2:2

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  15. Content type: Commentary

    The low-grade inflammation seen with aging is noted particularly in subjects with the metabolic syndrome of aging. Insulin resistance, obesity/abdominal obesity, and risks for many age-related diseases charact...

    Authors: Eric Rudin and Nir Barzilai

    Citation: Immunity & Ageing 2005 2:1

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  16. Content type: Short report

    In the recent years, several cytokines have been associated with Alzheimer's disease (AD) development and progression and many studies have correlated this risk with polymorphisms in the genes encoding these m...

    Authors: Lorenza Galimberti, Beatrice Arosio, Carmen Calabresi, Silvia Scurati, Susanna Hamilton, Simona Delli Carpini, Carlo Vergani and Giorgio Annoni

    Citation: Immunity & Ageing 2004 1:6

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  17. Content type: Research

    With advancing age, thymic efficiency shows progressive decline due to thymic involution allowing impaired cell-mediated immunity and the appearance of age-related diseases. The intrinsic cause of thymic invol...

    Authors: Eugenio Mocchegiani, Robertina Giacconi, Catia Cipriano, Elisa Muti, Nazzarena Gasparini and Marco Malavolta

    Citation: Immunity & Ageing 2004 1:5

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  18. Content type: Research

    Atherosclerosis lesions contain abundant immunoglobulins complexed with oxidized LDL (OxLDL) that are endocytosed by macrophages to form foam cells. While recent evidence supports a role for the macrophage sca...

    Authors: David C Calverley, Taya Varteresian, Elizabeth Brass, Denice D Tsao-Wei, Susan Groshen, Wendy J Mack, Thomas A Buchanan, Howard N Hodis and Alan D Schreiber

    Citation: Immunity & Ageing 2004 1:4

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  19. Content type: Review

    Only a small percentage of patients with Alzheimer's disease benefit from current drug therapy and for only a relatively short time. This is not surprising as the goal of these drugs is to enhance existing cer...

    Authors: Marc E Weksler

    Citation: Immunity & Ageing 2004 1:2

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