Figure 2
From: NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies
NF-kB system is at the hub of aging inflammatory network Its activation is induced by different factors, such as mitochondria dysfunction, oxidative stress, activation of Inflammasomes, decline of autophagic cleansing. Other NF-kB activators are activation of innate/inflammatory responses by PAMPs and DAMPs, elevated induction of insulin/IGF1 pathway, acetylation and O-glycosylation of components of NF-kB pathway, and DNA damage. NF-kB system induces entropic ageing process and release of SASP.