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Table 2 Potential therapeutic interventions and effects on targets of inflammatory network

From: NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies

Therapies Target effects
Monoclonal antibodies against these cytokines and their receptors Reduction of levels of IL-6, TNF-α
Non-steroidal anti-inflammatory drug  
Agonists of cytokine receptors or PRR receptors for people who do not respond to (or comply with) NSAID therapy  
Antibody-mediated stimulation of the decoy TLR receptors, such as TAM receptors, or of the intracellular TLR regulators for people with pro-inflammatory alleles in TLR4 and TLR2 genes  
Statin therapy  
Physical activity  
Administration of prebiotics and probiotics  
Caloric restriction Decrease of oxidative stress
Polyphenols  
Use of drugs having mimic CR action  
Caloric restriction Mitochondria biogenesis as preventive action against mitochondrial dysfunction
Use of drugs having mimic CR action  
Polyphenols  
Caloric restriction Reduction of the activation of NF-KB pathway
Terpenoids  
Resveratrol  
Use of specific miRNAs  
Administration of prebiotics and probiotics  
Use of drugs having mimic CR action Curcumin  
Caloric restriction: inhibition of mTOR pathway Preventive action on the possible reduced activity of autophagic cleansing
Rapamycin: inhibition of mTOR pathway  
Curcumin: influences the mTOR pathway  
Caloric restriction Reduction of the excessive activation of Insulin/IGF1 pathway
Metformin with CR mimic response