Table 1 Descriptive data of participants at baseline (N = 672) a
Entire cohort | |
|---|---|
Demographics | |
Participants, N (%) | 672 |
Age, mean (SD) | 80.4 (7.2) |
Sex (Female), N (%) | 544 (81.0) |
Race (white), N (%) | 513 (76.3) |
Years of Education, mean (SD) | 15.9 (3.5) |
Cognitive testing | |
Global cognitive function (t-score), mean (SD) | 50 (10) (N = 607) |
Working memory | 50 (10) (N = 606) |
Semantic memory | 50 (10) (N = 600) |
Perceptual speed | 50 (10) (N = 597) |
Perceptual orientation | 50 (10) (N = 593) |
Episodic memory | 50 (10) (N = 605) |
Clinical Diagnosis at ccf-mtDNA Visit | |
No cognitive impairment (NCI) | 633 (94.2) |
Mild cognitive impairment (MCI) | 17 (2.5) |
Alzheimer’s Dementia (AD) | 18 (2.7) |
Physical measures | |
Frailty z-score, mean (SD) b | -0.07 (0.55) (N = 548) |
Grip strength (lbs), mean (SD) | 46.1 (16.9) (N = 411) |
Gait speed (m/s), mean (SD) | 0.64 (0.20) (N = 539) |
Motor gait z-score, mean (SD) c | 1.02 (0.26) (N = 576) |
Motor composite z-score, mean (SD) d | 1.00 (0.25) (N = 559) |
CCF-mtDNA | |
Short ccf-mtDNA (1000 copies/µl), mean (SD) | 0.39 (0.29) |
Long ccf-mtDNA (1000 copies/µl), mean (SD) | 0.16 (0.17) |
Inflammatory markers | |
C-Reactive Protein (µg/ml), mean (SD) | 1.3 (0.8) (N = 658) |
sTNFR1(pg/ml), mean (SD) | 7.4 (0.4) (N = 657) |
Tumor necrosis factor ⍺ (pg/ml), mean (SD) | 1.5 (0.6) (N = 659) |
Interleukin-6 (pg/ml), mean (SD) | 0.9 (0.6) (N = 659) |