Outcomes | Short ccf-mtDNA β (95% CI) | Long ccf-mtDNA β (95% CI) |
|---|
CRP |
0.47 (0.25, 0.69)
|
0.61 (0.20, 1.02)
|
sTNFR1 |
0.15 (0.07, 0.23)
| 0.14 (-0.02, 0.29) |
TNF⍺ |
0.51 (0.33, 0.70)
|
0.61 (0.30, 0.92)
|
IL-6 |
0.41 (0.26, 0.56)
|
0.46 (0.21, 0.70)
|
- Abbreviations: CI = Confidence interval; CRP = C-Reactive protein; ccf-mtDNA = circulating cell-free mitochondrial DNA; IL-6 = interleukin-6; TNF⍺ = Tumor necrosis factor ⍺; sTNFR1 = soluble Tumor necrosis factor ⍺ receptor 1
- Coefficients represent the difference in the outcome per 1000 copies per µL change in the ccf-mtDNA predictor on the log scale. Inflammatory variables were log-transformed. Generalized estimating equations (GEE) were used to estimate the association between ccf-mtDNA and inflammatory markers. Each coefficient was estimated from a separate GEE model. All models adjusted for baseline age, sex, race, and education. Bold indicates p < 0.05
