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Fig. 2 | Immunity & Ageing

Fig. 2

From: TBX21, the Master regulator of the type 1 immune response, overexpresses in the leukocytes of peripheral blood in patients with late-onset Alzheimer’s disease

Fig. 2

Relative levels of TBX21 mRNAs in peripheral blood leukocyte samples of designated genotypes in a rs41515744 polymorphism for genotypes of CC (155), CT (33), and TT (6) and in b rs17244587 polymorphism for genotypes of GG (178), GA (6), and AA (10). (n = 194 in patients and n = 200 in control groups). The differences between groups are marked in the figure. The increase in TBX21 mRNA levels was higher in the C/T of the rs41515744 genotype than in the two other genotypes in the LOAD patients. The differences between LOAD and control samples in TBX21 expression of the CC and TT genotypes are shown to be significant (****P < 0.0001). The increase in TBX21 mRNA levels was higher in the G/G of the rs17244587 genotype than in the two other genotypes in the LOAD patients. The differences between LOAD and control samples in TBX21 expression of the GG and GA genotypes are shown to be significant (****P < 0.0001). Barres in box plots represent mean values ± SDs. We used a Kruskal_Wallis test to compare the different groups (****P < 0.0001). LOAD, late-onset Alzheimer’s disease

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Immunity & Ageing

ISSN: 1742-4933

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