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  1. T cell-mediated immunity in elderly people is compromised in ways reflected in the composition of the peripheral T cell pool. The advent of polychromatic flow cytometry has made analysis of cell subsets feasib...

    Authors: Sven Koch, Anis Larbi, Evelyna Derhovanessian, Dennis Özcelik, Elissaveta Naumova and Graham Pawelec
    Citation: Immunity & Ageing 2008 5:6
  2. Chronic inflammation is a well-known corollary of the aging process and is believed to significantly contribute to morbidity and mortality of many age-associated chronic diseases. However, the mechanisms that ...

    Authors: Andres Kriete, Kelli L Mayo, Nirupama Yalamanchili, William Beggs, Patrick Bender, Csaba Kari and Ulrich Rodeck
    Citation: Immunity & Ageing 2008 5:5
  3. Nitric oxide (NO) synthesized by endothelial nitric oxide synthase (eNOS) plays an important role in regulation of endothelial function and in the control of blood pressure. However, the results from some stud...

    Authors: Daniela Colomba, Giovanni Duro, Salvatore Corrao, Christiano Argano, Tiziana Di Chiara, Domenico Nuzzo, Federica Pizzo, Gaspare Parrinello, Rosario Scaglione and Giuseppe Licata
    Citation: Immunity & Ageing 2008 5:4
  4. The safety and immunogenicity of an MF59™-adjuvanted subunit influenza vaccine (Sub/MF59™; FLUAD®, Novartis Vaccines) was evaluated among elderly Chinese subjects (≥ 60 years of age). After a preliminary Phase I,...

    Authors: Rongcheng Li, Hanhua Fang, Yanping Li, Youping Liu, Michele Pellegrini and Audino Podda
    Citation: Immunity & Ageing 2008 5:2
  5. The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly peo...

    Authors: Richard Aspinall, Giuseppe Del Giudice, Rita B Effros, Beatrix Grubeck-Loebenstein and Suryaprakash Sambhara
    Citation: Immunity & Ageing 2007 4:9
  6. The mechanism explaining the increased disease susceptibility in aging is not well understood. CD8+ T cells are crucial in anti-viral and anti-tumor responses. Although the chemokine system plays a critical ro...

    Authors: Raymond Yung, RuRan Mo, Annabelle Grolleau-Julius and Mark Hoeltzel
    Citation: Immunity & Ageing 2007 4:8
  7. The capacity of the remodelling immune responses during stress (named immune plasticity) is fundamental to reach successful ageing. We herein report two pivotal experimental models in order to demonstrate the ...

    Authors: Eugenio Mocchegiani, Robertina Giacconi, Elisa Muti, Catia Cipriano, Laura Costarelli, Silvia Tesei, Nazzarena Gasparini and Marco Malavolta
    Citation: Immunity & Ageing 2007 4:7
  8. The importance of Zn for optimal functioning of the immune system and antioxidant stress response is well documented. Zn homeostasis influences development and function of immune cells, activity of stress-rela...

    Authors: Eugenio Mocchegiani
    Citation: Immunity & Ageing 2007 4:5
  9. On April 18, 2007 an international meeting on Pathophysiology of Ageing, Longevity and Age-Related Diseases was held in Palermo, Italy. Several interesting topics on Cancer, Immunosenescence, Age-related infla...

    Authors: Alexander Bürkle, Graziella Caselli, Claudio Franceschi, Erminia Mariani, Paolo Sansoni, Angela Santoni, Giancarlo Vecchio, Jacek M Witkowski and Calogero Caruso
    Citation: Immunity & Ageing 2007 4:4
  10. Viral and bacterial infections have been considered as a risk factor for Coronary Heart Disease (CHD). NK cells, as a first line of defense against those infections, may play a role in CHD development. Thus, t...

    Authors: Łukasz Hak, Jolanta Myśliwska, Joanna Więckiewicz, Krzysztof Szyndler, Piotr Trzonkowski, Janusz Siebert and Andrzej Myśliwski
    Citation: Immunity & Ageing 2007 4:3
  11. Ageing is associated with declines in many physiological parameters, including multiple immune system functions. The rate of acceleration of the frequency of death due to cardiovascular disease or cancer seems...

    Authors: Sonya Vasto, Giuseppina Colonna-Romano, Anis Larbi, Anders Wikby, Calogero Caruso and Graham Pawelec
    Citation: Immunity & Ageing 2007 4:2
  12. We describe the inflammation pathway from Cholesterol to Aging. Interleukin 6 mediated inflammation is implicated in age-related disorders including Atherosclerosis, Peripheral Vascular Disease, Coronary Arter...

    Authors: Sota Omoigui
    Citation: Immunity & Ageing 2007 4:1
  13. Cellular immunity plays a crucial role in cytomegalovirus (CMV) infection and substantial populations of CMV-specific T cells accumulate throughout life. However, although CMV infection occurs during childhood...

    Authors: Haruki Komatsu, Ayano Inui, Tsuyoshi Sogo, Tomoo Fujisawa, Hironori Nagasaka, Shigeaki Nonoyama, Sophie Sierro, John Northfield, Michaela Lucas, Anita Vargas and Paul Klenerman
    Citation: Immunity & Ageing 2006 3:11
  14. a decline in immune and endocrine function occurs with aging. The main purpose of this study was to investigate the impact of long-term endurance training on the immune and endocrine system of elderly men. The...

    Authors: Milton Hideaki Arai, Alberto JS Duarte and Valéria Maria Natale
    Citation: Immunity & Ageing 2006 3:9
  15. Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins catalysed by poly(ADP-ribose) polymerases (PARPs), using NAD+ as a substrate. Activation of PARP-1 is in immediate response to DNA da...

    Authors: Andrea Kunzmann, Dan Liu, Kathryn Annett, Muriel Malaisé, Bastian Thaa, Paul Hyland, Yvonne Barnett and Alexander Bürkle
    Citation: Immunity & Ageing 2006 3:8
  16. An inexpensive Plexiglas apparatus which allows a simple and rapid preparation of horizontal polyacrylamide gels of different dimensions for different purposes, is described. Preparation of such gels is as eas...

    Authors: Vincenzo Izzo, Maria A Costa, Renata Di Fiore, Giovanni Duro, Daniele Bellavia, Eleonora Cascone, Paolo Colombo, Maria C Gioviale and Rainer Barbieri
    Citation: Immunity & Ageing 2006 3:7
  17. The relevance of zinc for proper functioning of the entire immune system is already well documented. However, the identification of individuals who really need zinc supplementation is still debated in view of ...

    Authors: Eugenio Mocchegiani, Marco Malavolta, Fiorella Marcellini and Graham Pawelec
    Citation: Immunity & Ageing 2006 3:6
  18. Aging is associated with a paradox of immunodeficiency and inflammation (an evidence of hyperactive immune system). Apoptosis is associated with cellular depletion and suppression of inflammatory response. In ...

    Authors: Sudhir Gupta, Anshu Agrawal, Sudhanshu Agrawal, Houfen Su and Sastry Gollapudi
    Citation: Immunity & Ageing 2006 3:5
  19. The functional changes associated with endothelial senescence may be involved in human aging and age-related vascular disorders. Since the inflammatory cytokine interleukin (IL-)1 inhibits endothelial growth, ...

    Authors: Massimo Mariotti, Sara Castiglioni, Daniela Bernardini and Jeanette AM Maier
    Citation: Immunity & Ageing 2006 3:4
  20. The number of old and oldest old patients undergoing surgery of varying severity is increasing. Ageing is a process that changes the performances of most physiological systems and increases susceptibility to d...

    Authors: Gaetano Di Vita, Carmela Rita Balistreri, Francesco Arcoleo, Salvatore Buscemi, Enrico Cillari, Marcello Donati, Maria Garofalo, Florinda Listì, Maria Paola Grimaldi, Rosalia Patti and Giuseppina Candore
    Citation: Immunity & Ageing 2006 3:3
  21. Longitudinal studies are defining progressive alterations to the immune system associated with increased mortality in the very elderly. Many of these changes are exacerbated by or even caused by chronic T cell...

    Authors: Sonya Vasto, Marco Malavolta and Graham Pawelec
    Citation: Immunity & Ageing 2006 3:2
  22. Aging is associated with a decline in immune function (immunosenescence), a situation known to correlate with increased incidence of cancer, infectious and degenerative diseases. Innate, cellular and humoral i...

    Authors: V Srinivasan, GJM Maestroni, DP Cardinali, AI Esquifino, SR Pandi Perumal and SC Miller
    Citation: Immunity & Ageing 2005 2:17
  23. The problems associated with the ageing immune system and vaccination were discussed recently at an international workshop at the Jenner Institute for Vaccine Research, Compton, UK, 6–7 October, 2005. This is ...

    Authors: Graham Pawelec
    Citation: Immunity & Ageing 2005 2:16
  24. Osteoporosis is a condition characterized by low bone mass and increased bone fragility, putting patients at risk of fractures, which are major causes of morbidity substantially in older people. Osteoporosis i...

    Authors: Lia Ginaldi, Maria Cristina Di Benedetto and Massimo De Martinis
    Citation: Immunity & Ageing 2005 2:14
  25. There is strong evidence that an individual's genetic background is an important predisposing factor to longevity. In the present study we analysed the frequency of HLA class I, class II, as well as the TNF-α ...

    Authors: Elena Soto-Vega, Yvonne Richaud-Patin and Luis Llorente
    Citation: Immunity & Ageing 2005 2:13
  26. Human aging is associated with progressive decline in immune functions, increased frequency of infections. Among immune functions, a decline in T cell functions during aging predominates. In this review, we wi...

    Authors: Sudhir Gupta, Houfen Su, Ruifen Bi, Sudhanshu Agrawal and Sastry Gollapudi
    Citation: Immunity & Ageing 2005 2:12
  27. A common feature of Alzheimer's disease (AD) pathology is the abundance of activated microglia in neuritic plaques containing amyloid-beta protein (Aβ) and associated molecules including heparan sulfate proteo...

    Authors: Simona Bussini, Lucia Meda, Elio Scarpini, Emilio Clementi, Giancarlo Conti, Marco Tiriticco, Nereo Bresolin and Pierluigi Baron
    Citation: Immunity & Ageing 2005 2:11
  28. Streptococcus pneumoniae is a serious worldwide pathogen and the focus of numerous vaccine development projects. Currently the most widely accepted surrogate marker for evaluating the efficacy of a given vaccine ...

    Authors: Kris Kolibab, S Louise Smithson, Anne K Shriner, Sadik Khuder, Sandra Romero-Steiner, George M Carlone and MA Julie Westerink
    Citation: Immunity & Ageing 2005 2:10
  29. Concerning allergic diseases, the incidence of allergic symptoms, as well as their severity, seems to decrease with age. The decline of onset of allergic symptoms observed in ageing might result from a decreas...

    Authors: Anja Mediaty and Karsten Neuber
    Citation: Immunity & Ageing 2005 2:9
  30. The process of maintaining life for the individual is a constant struggle to preserve his/her integrity. This can come at a price when immunity is involved, namely systemic inflammation. Inflammation is not pe...

    Authors: Federico Licastro, Giuseppina Candore, Domenico Lio, Elisa Porcellini, Giuseppina Colonna-Romano, Claudio Franceschi and Calogero Caruso
    Citation: Immunity & Ageing 2005 2:8
  31. Roy Walford died on April 27, 2004, at the age of 79. His contributions to gerontological research in such diverse areas as caloric restriction, genetics of lifespan, immunosenescence, DNA repair and replicati...

    Authors: Rita B Effros
    Citation: Immunity & Ageing 2005 2:7
  32. Neutrophils represent the first line of defence against aggressions. The programmed death of neutrophils is delayed by pro-inflammatory stimuli to ensure a proper resolution of the inflammation in time and pla...

    Authors: Anis Larbi, Nadine Douziech, Carl Fortin, Annie Linteau, Gilles Dupuis and Tamas Fulop Jr
    Citation: Immunity & Ageing 2005 2:6
  33. The problems associated with the ageing immune system coupled with possible solutions were discussed recently at the British Society for Immunology Annual Congress in Harrogate in December 2004. The session "A...

    Authors: Richard Aspinall
    Citation: Immunity & Ageing 2005 2:5
  34. Down's syndrome (DS) is characterized by several immunological defects, especially regarding T cell compartment. DS is considered the best example of accelerated ageing in humans. Direct observations of the th...

    Authors: Nicole Prada, Milena Nasi, Leonarda Troiano, Erika Roat, Marcello Pinti, Elisa Nemes, Enrico Lugli, Roberta Ferraresi, Luigi Ciacci, Davide Bertoni, Ornella Biagioni, Milena Gibertoni, Cristina Cornia, Liviana Meschiari, Elisabetta Gramazio, Mauro Mariotti…
    Citation: Immunity & Ageing 2005 2:4
  35. In a previous study we demonstrated the existence of numerical and functional alterations of γδ T cells in healthy elderly. Recently, we analysed the involvement of γδ T lymphocytes in malignant melanoma, desc...

    Authors: Francesca Re, Alessia Donnini, Beatrice Bartozzi, Giovanni Bernardini and Mauro Provinciali
    Citation: Immunity & Ageing 2005 2:2
  36. The low-grade inflammation seen with aging is noted particularly in subjects with the metabolic syndrome of aging. Insulin resistance, obesity/abdominal obesity, and risks for many age-related diseases charact...

    Authors: Eric Rudin and Nir Barzilai
    Citation: Immunity & Ageing 2005 2:1
  37. In the recent years, several cytokines have been associated with Alzheimer's disease (AD) development and progression and many studies have correlated this risk with polymorphisms in the genes encoding these m...

    Authors: Lorenza Galimberti, Beatrice Arosio, Carmen Calabresi, Silvia Scurati, Susanna Hamilton, Simona Delli Carpini, Carlo Vergani and Giorgio Annoni
    Citation: Immunity & Ageing 2004 1:6
  38. With advancing age, thymic efficiency shows progressive decline due to thymic involution allowing impaired cell-mediated immunity and the appearance of age-related diseases. The intrinsic cause of thymic invol...

    Authors: Eugenio Mocchegiani, Robertina Giacconi, Catia Cipriano, Elisa Muti, Nazzarena Gasparini and Marco Malavolta
    Citation: Immunity & Ageing 2004 1:5
  39. Atherosclerosis lesions contain abundant immunoglobulins complexed with oxidized LDL (OxLDL) that are endocytosed by macrophages to form foam cells. While recent evidence supports a role for the macrophage sca...

    Authors: David C Calverley, Taya Varteresian, Elizabeth Brass, Denice D Tsao-Wei, Susan Groshen, Wendy J Mack, Thomas A Buchanan, Howard N Hodis and Alan D Schreiber
    Citation: Immunity & Ageing 2004 1:4
  40. Only a small percentage of patients with Alzheimer's disease benefit from current drug therapy and for only a relatively short time. This is not surprising as the goal of these drugs is to enhance existing cer...

    Authors: Marc E Weksler
    Citation: Immunity & Ageing 2004 1:2

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