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  1. While influenza vaccination results in protective antibodies against primary infections, clearance of infection is primarily mediated through CD8+ T cells. Studying the CD8+ T cell response to influenza epitopes ...

    Authors: Jessica B Lee, Mathias Oelke, Lakshmi Ramachandra, David H Canaday and Jonathan P Schneck

    Citation: Immunity & Ageing 2011 8:6

    Content type: Research

    Published on:

  2. With the progressive aging of the human population, there is an inexorable decline in muscle mass, strength and function. Anabolic supplementation with testosterone has been shown to effectively restore muscle...

    Authors: Camellia Banerjee, Jagadish Ulloor, Edgar L Dillon, Qusai Dahodwala, Brittani Franklin, Thomas Storer, Paola Sebastiani, Melinda Sheffield-Moore, Randall J Urban, Shalender Bhasin and Monty Montano

    Citation: Immunity & Ageing 2011 8:5

    Content type: Research

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  3. The increase in life expectancy within the general population has resulted in an increasing number of elderly adults, including patients with Down syndrome (DS), with a current life expectancy of about 50 year...

    Authors: Maria BF Trotta, João B Serro Azul, Mauricio Wajngarten, Simone G Fonseca, Anna C Goldberg and Jorge E Kalil

    Citation: Immunity & Ageing 2011 8:4

    Content type: Research

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  4. Cytomegalovirus (CMV) is a prevalent herpesvirus with links to both stress and aging. This paper describes and validates a minimally invasive method for assessing antibodies against CMV in finger stick whole b...

    Authors: Jennifer B Dowd, Allison E Aiello, Laura Chyu, Yuan-yen Huang and Thomas W McDade

    Citation: Immunity & Ageing 2011 8:3

    Content type: Methodology

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  5. The age- and cytomegalovirus (CMV)-seropositivity-related changes in subsets and differentiation of circulating T cells were investigated in end-stage renal disease (ESRD) patients (n = 139) and age-matched he...

    Authors: Nicolle HR Litjens, Elly A de Wit and Michiel GH Betjes

    Citation: Immunity & Ageing 2011 8:2

    Content type: Research

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  6. Immunosenescence is the age-related decline and dysfunction of protective immunity leading to a marked increase in the risk of infections, autoimmune disease, and cancer. The majority of studies have focused o...

    Authors: Keely G McDonald, Matthew R Leach, Conway Huang, Caihong Wang and Rodney D Newberry

    Citation: Immunity & Ageing 2011 8:1

    Content type: Research

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  7. Alzheimer’s disease (AD) is one of the most frequent cause of neurodegenerative disorder in the elderly. Inflammation has been implicated in brain degenerative processes and peripheral markers of brain AD rela...

    Authors: Manuela Ianni, Marcella Manerba, Giuseppina Di Stefano, Elisa Porcellini, Martina Chiappelli, Ilaria Carbone and Federico Licastro

    Citation: Immunity & Ageing 2010 7(Suppl 1):S6

    Content type: Proceedings

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    This article is part of a Supplement: Volume 7 Supplement 1

  8. It has been reported that cellular prion protein (PrPc) co-localizes with caveolin-1 and participates to signal transduction events by recruiting Fyn kinase. As PrPc is a secreted protein anchored to the outer su...

    Authors: Vittorio Tomasi

    Citation: Immunity & Ageing 2010 7(Suppl 1):S5

    Content type: Proceedings

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  9. The population longitudinal study named “The Conselice Study” has been the focus of the present investigation. 65 years old or older participants of this population study on brain aging were followed up for 5 ...

    Authors: Federico Licastro, Elisa Porcellini, Paola Forti, Massimo Buscema, Ilaria Carbone, Giovanni Ravaglia and Enzo Grossi

    Citation: Immunity & Ageing 2010 7(Suppl 1):S4

    Content type: Proceedings

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  10. An individual patient is not the average representative of the population. Rather he or she is a person with unique characteristics. An intervention may be effective for a population but not necessarily for th...

    Authors: Enzo Grossi

    Citation: Immunity & Ageing 2010 7(Suppl 1):S3

    Content type: Proceedings

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  11. Among the age-related diseases, the development of cognitive impairments, in particular dementia, is the most devastating for the individual and has great social and healthcare costs. Accurate information is n...

    Authors: Giovanni Ravaglia and Paola Forti

    Citation: Immunity & Ageing 2010 7(Suppl 1):S2

    Content type: Proceedings

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  12. Progressive increase of mean age and life expectancy in both industrialized and emerging societies parallels an increment of chronic degenerative diseases (CDD) such as cancer, cardiovascular, autoimmune or ne...

    Authors: Federico Licastro and Calogero Caruso

    Citation: Immunity & Ageing 2010 7(Suppl 1):S1

    Content type: Proceedings

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  13. Periodontal disease is a chronic inflammatory gum disease that in severe cases leads to tooth loss. Porphyromonas gingivalis (Pg) is a bacterium closely associated with generalized forms of periodontal disease. C...

    Authors: Yazdani B Shaik-Dasthagirisaheb, Alpdogan Kantarci and Frank C Gibson III

    Citation: Immunity & Ageing 2010 7:15

    Content type: Short report

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  14. Respiratory syncytial virus (RSV) is the major pathogen causing respiratory disease in young infants and it is an important cause of serious illness in the elderly since the infection provides limited immune p...

    Authors: Maria Grazia Cusi, Barbara Martorelli, Giuseppa Di Genova, Chiara Terrosi, Giuseppe Campoccia and Pierpaolo Correale

    Citation: Immunity & Ageing 2010 7:14

    Content type: Research

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  15. The tuberculosis (TB) still increases in the number of new cases, which is estimated to approach 10 million in 2010. The number of aged people has been growing all over the world. Ageing is one of risk factors...

    Authors: Tsukasa Ito, Takemasa Takii, Mitsuo Maruyama, Daisuke Hayashi, Takeshi Wako, Azusa Asai, Yasuhiro Horita, Keiichi Taniguchi, Ikuya Yano, Saburo Yamamoto and Kikuo Onozaki

    Citation: Immunity & Ageing 2010 7:12

    Content type: Short report

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  16. Immunoglobulin A (IgA) secretion in saliva decreases with age and may be the cause of increased vulnerability of the elderly to respiratory infections. The effect of oral intake of lactic acid bacteria on sali...

    Authors: Yoshifumi Kotani, Shoji Shinkai, Hiroshi Okamatsu, Masamichi Toba, Kishiko Ogawa, Hiroto Yoshida, Taro Fukaya, Yoshinori Fujiwara, Paulo HM Chaves, Keiji Kakumoto and Noriyuki Kohda

    Citation: Immunity & Ageing 2010 7:11

    Content type: Research

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  17. The immune system gradually deteriorates with age and nutritional status is a major factor in immunosenescence. Of the many nutritional factors implicated in age-related immune dysfunction, vitamin A may be a ...

    Authors: Régine Minet-Quinard, M Chantal Farges, Emilie Thivat, Cécile Deleine, Gilles Mayot, Julius Brtko, Josep Ribalta, Brigitte Winklhofer-Roob, Edmond Rock and M Paule Vasson

    Citation: Immunity & Ageing 2010 7:10

    Content type: Research

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  18. Infectious diseases are significant causes of morbidity and mortality among elderly populations. However, the relationship between oxidative stress, immune function and inflammatory response in acute phase of ...

    Authors: Thi Kim Duy Vo, Patrice Godard, Marie de Saint-Hubert, Gabriel Morrhaye, Christian Swine, Vincent Geenen, Henri J Martens, Florence Debacq-Chainiaux and Olivier Toussaint

    Citation: Immunity & Ageing 2010 7:9

    Content type: Research

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  19. The increasing ratio of ageing population poses new challenges to healthcare systems. The elderly frequently suffer from severe infections. Vaccination could protect them against several infectious diseases, b...

    Authors: Joseph Ongrádi and Valéria Kövesdi

    Citation: Immunity & Ageing 2010 7:7

    Content type: Review

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  20. There is reported to be a decline in immune function and an alteration in the frequency of circulating lymphocytes with advancing age. There are also differences in ageing and lifespan between males and female...

    Authors: Jun Yan, Judith M Greer, Renee Hull, John D O'Sullivan, Robert D Henderson, Stephen J Read and Pamela A McCombe

    Citation: Immunity & Ageing 2010 7:4

    Content type: Research

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  21. Oncogenic γ-herpesviruses establish life-long infections in their hosts and control of these latent infections is dependent on continual immune surveillance. Immune function declines with age, raising the poss...

    Authors: Eric J Yager, In-Jeong Kim, Michael L Freeman, Kathleen G Lanzer, Claire E Burkum, Tres Cookenham, David L Woodland and Marcia A Blackman

    Citation: Immunity & Ageing 2010 7:3

    Content type: Research

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  22. The prevalence of coronary artery diseases is low among Down Syndrome (DS) patients and they rarely die of atherosclerotic complications. Histopathological investigations showed no increase in atherosclerosis,...

    Authors: Giada Dogliotti, Emanuela Galliera, Federico Licastro and Massimiliano M Corsi

    Citation: Immunity & Ageing 2010 7:2

    Content type: Short report

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  23. A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy between April 7 and 8th 2009. Here the lecture by Sikora with some input from the chairpersons Scapagnini...

    Authors: E Sikora, Giovanni Scapagnini and Mario Barbagallo

    Citation: Immunity & Ageing 2010 7:1

    Content type: Review

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  24. The concept of Vascular Dementia (VaD) has been recognized for over a century, but its definition and diagnostic criteria remain unclear.

    Authors: Francesco Iemolo, Giovanni Duro, Claudia Rizzo, Laura Castiglia, Vladimir Hachinski and Calogero Caruso

    Citation: Immunity & Ageing 2009 6:13

    Content type: Review

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  25. A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy on 7-8 April 2009. Three lectures from that Symposium by G. Campisi, L. Ginaldi and F. Licastro are here ...

    Authors: Giuseppina Campisi, Martina Chiappelli, Massimo De Martinis, Vito Franco, Lia Ginaldi, Rosario Guiglia, Federico Licastro and Domenico Lio

    Citation: Immunity & Ageing 2009 6:12

    Content type: Review

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  26. Ageing is associated with changes in the immune system with substantial alterations in T-lymphocyte subsets. Cytomegalovirus (CMV) is one of the factors that affect functionality of T cells and the differentia...

    Authors: María Luisa Pita-Lopez, Inmaculada Gayoso, Olga DelaRosa, Javier G Casado, Corona Alonso, Elisa Muñoz-Gomariz, Raquel Tarazona and Rafael Solana

    Citation: Immunity & Ageing 2009 6:11

    Content type: Research

    Published on:

  27. On April 7,8, 2009 a Symposium entitled "Pathophysiology of Successful and Unsuccessful Ageing" took place in Palermo, Italy. Here, the lectures of G. Pawelec, D. Dunn-Walters and. G. Colonna-Romano on T and B...

    Authors: Calogero Caruso, Silvio Buffa, Giuseppina Candore, Giuseppina Colonna-Romano, Deborah Dunn-Walters, David Kipling and Graham Pawelec

    Citation: Immunity & Ageing 2009 6:10

    Content type: Short report

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  28. The trace element zinc is essential for the immune system, and zinc deficiency affects multiple aspects of innate and adaptive immunity. There are remarkable parallels in the immunological changes during aging...

    Authors: Hajo Haase and Lothar Rink

    Citation: Immunity & Ageing 2009 6:9

    Content type: Review

    Published on:

  29. Rheumatoid arthritis (RA) most often begins in females in the fourth-fifth decade of their life, suggesting that the aging of the immune system (immunosenescence) has a major role in this disease. Therefore, i...

    Authors: Oktavia Tarjanyi, Ferenc Boldizsar, Peter Nemeth, Katalin Mikecz and Tibor T Glant

    Citation: Immunity & Ageing 2009 6:8

    Content type: Research

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  30. The innate immune system plays an important role in the recognition and induction of protective responses against infectious pathogens, whilst there is increasing evidence for a role in mediating chronic infla...

    Authors: Linda May, Anita HJ van den Biggelaar, David van Bodegom, Hans J Meij, Anton JM de Craen, Joseph Amankwa, Marijke Frölich, Maris Kuningas and Rudi GJ Westendorp

    Citation: Immunity & Ageing 2009 6:7

    Content type: Research

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  31. A method is described that allows an accurate mapping of 3' ends of RNAs. In this method a labeled DNA probe, containing the presumed 3' end of the RNA under analysis is allowed to anneals to the RNA itself. M...

    Authors: Daniele Bellavia, Giorgia Sisino, Giorgio L Papadopoulos, Giusi I Forte and Rainer Barbieri

    Citation: Immunity & Ageing 2009 6:6

    Content type: Short report

    Published on:

  32. Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder that belongs to a group of conditions called laminopathies which affect nuclear lamins. Mutations in two genes, LMNA and ZMPSTE24,...

    Authors: Henrique Douglas M Coutinho, Vivyanne S Falcão-Silva, Gregório Fernandes Gonçalves and Raphael Batista da Nóbrega

    Citation: Immunity & Ageing 2009 6:4

    Content type: Review

    Published on:

  33. Ageing leads to a decline in the function of the immune system, increasing the body's susceptibility to infections through the impairment of T-cells, macrophages, neutrophils and dendritic cells Denture stomat...

    Authors: Thaís Helena Gasparoto, Narciso Almeida Vieira, Vinicius Carvalho Porto, Ana Paula Campanelli and Vanessa Soares Lara

    Citation: Immunity & Ageing 2009 6:3

    Content type: Research

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  34. Immunosenescence is an age-associated disorder occurring primarily in T cell compartments, including altered subset composition, functions, and activation. In women, evidence implicates diminished estrogen in ...

    Authors: Lowell T Ku, Cicek Gercel-Taylor, Steven T Nakajima and Douglas D Taylor

    Citation: Immunity & Ageing 2009 6:1

    Content type: Research

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  35. Ageing is associated with dysfunction in the humoral response leading to decreased protection against infectious diseases. Defects in T cell function due to age have been well characterized but it is unclear i...

    Authors: Anthony Blaeser, Kiley McGlauchlen and Laura A Vogel

    Citation: Immunity & Ageing 2008 5:15

    Content type: Research

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  36. Old age is associated with characteristic changes of the immune system contributing to higher incidence and severity of many infectious diseases. Particularly within the T cell compartment latent infection wit...

    Authors: Angelika Schwanninger, Birgit Weinberger, Daniela Weiskopf, Dietmar Herndler-Brandstetter, Stephan Reitinger, Christoph Gassner, Harald Schennach, Walther Parson, Reinhard Würzner and Beatrix Grubeck-Loebenstein

    Citation: Immunity & Ageing 2008 5:14

    Content type: Short report

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  37. Reactive oxygen species (ROS), including free radicals, oxygen ions, and peroxides, are implicated in cell damage. The objective of this study was to investigate whether the spontaneous production of ROS from ...

    Authors: Kishiko Ogawa, Katsuhiko Suzuki, Mitsuharu Okutsu, Kyoko Yamazaki and Shoji Shinkai

    Citation: Immunity & Ageing 2008 5:13

    Content type: Research

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  38. On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related Diseases was held in Palermo, Italy. The lecture of D. Mari on Hemostasis and ageing is summarized herein. Physiological ageing is ass...

    Authors: Daniela Mari, Giulia Ogliari, Davide Castaldi, Giovanni Vitale, Elisa Mariadele Bollini and Domenico Lio

    Citation: Immunity & Ageing 2008 5:12

    Content type: Short report

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  39. Compromised immunity contributes to the decreased ability of the elderly to control infectious disease and to their generally poor response to vaccination. It is controversial as to how far this phenomenon con...

    Authors: Evelyna Derhovanessian, Rafael Solana, Anis Larbi and Graham Pawelec

    Citation: Immunity & Ageing 2008 5:11

    Content type: Review

    Published on:

  40. On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related diseases was held in Palermo, Italy. Here, the lecture of V. Nicita-Mauro on Smoking, health and ageing is summarized. Smoking represe...

    Authors: Vittorio Nicita-Mauro, Giorgio Basile, Giuseppe Maltese, Claudio Nicita-Mauro, Sebastiano Gangemi and Calogero Caruso

    Citation: Immunity & Ageing 2008 5:10

    Content type: Short report

    Published on:

  41. During the past century, humans have gained more years of average life expectancy than in the last 10,000 years; we are now living in a rapidly ageing world. The sharp rise in life expectancy, coupled to a ste...

    Authors: Matteo Bulati, Mariavaleria Pellicanò, Sonya Vasto and Giuseppina Colonna-Romano

    Citation: Immunity & Ageing 2008 5:9

    Content type: Short report

    Published on:

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