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  1. A method is described that allows an accurate mapping of 3' ends of RNAs. In this method a labeled DNA probe, containing the presumed 3' end of the RNA under analysis is allowed to anneals to the RNA itself. M...

    Authors: Daniele Bellavia, Giorgia Sisino, Giorgio L Papadopoulos, Giusi I Forte and Rainer Barbieri

    Citation: Immunity & Ageing 2009 6:6

    Content type: Short report

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  3. Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder that belongs to a group of conditions called laminopathies which affect nuclear lamins. Mutations in two genes, LMNA and ZMPSTE24,...

    Authors: Henrique Douglas M Coutinho, Vivyanne S Falcão-Silva, Gregório Fernandes Gonçalves and Raphael Batista da Nóbrega

    Citation: Immunity & Ageing 2009 6:4

    Content type: Review

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  4. Ageing leads to a decline in the function of the immune system, increasing the body's susceptibility to infections through the impairment of T-cells, macrophages, neutrophils and dendritic cells Denture stomat...

    Authors: Thaís Helena Gasparoto, Narciso Almeida Vieira, Vinicius Carvalho Porto, Ana Paula Campanelli and Vanessa Soares Lara

    Citation: Immunity & Ageing 2009 6:3

    Content type: Research

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  6. Immunosenescence is an age-associated disorder occurring primarily in T cell compartments, including altered subset composition, functions, and activation. In women, evidence implicates diminished estrogen in ...

    Authors: Lowell T Ku, Cicek Gercel-Taylor, Steven T Nakajima and Douglas D Taylor

    Citation: Immunity & Ageing 2009 6:1

    Content type: Research

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  8. Ageing is associated with dysfunction in the humoral response leading to decreased protection against infectious diseases. Defects in T cell function due to age have been well characterized but it is unclear i...

    Authors: Anthony Blaeser, Kiley McGlauchlen and Laura A Vogel

    Citation: Immunity & Ageing 2008 5:15

    Content type: Research

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  9. Old age is associated with characteristic changes of the immune system contributing to higher incidence and severity of many infectious diseases. Particularly within the T cell compartment latent infection wit...

    Authors: Angelika Schwanninger, Birgit Weinberger, Daniela Weiskopf, Dietmar Herndler-Brandstetter, Stephan Reitinger, Christoph Gassner, Harald Schennach, Walther Parson, Reinhard Würzner and Beatrix Grubeck-Loebenstein

    Citation: Immunity & Ageing 2008 5:14

    Content type: Short report

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  10. Reactive oxygen species (ROS), including free radicals, oxygen ions, and peroxides, are implicated in cell damage. The objective of this study was to investigate whether the spontaneous production of ROS from ...

    Authors: Kishiko Ogawa, Katsuhiko Suzuki, Mitsuharu Okutsu, Kyoko Yamazaki and Shoji Shinkai

    Citation: Immunity & Ageing 2008 5:13

    Content type: Research

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  11. On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related Diseases was held in Palermo, Italy. The lecture of D. Mari on Hemostasis and ageing is summarized herein. Physiological ageing is ass...

    Authors: Daniela Mari, Giulia Ogliari, Davide Castaldi, Giovanni Vitale, Elisa Mariadele Bollini and Domenico Lio

    Citation: Immunity & Ageing 2008 5:12

    Content type: Short report

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  12. Compromised immunity contributes to the decreased ability of the elderly to control infectious disease and to their generally poor response to vaccination. It is controversial as to how far this phenomenon con...

    Authors: Evelyna Derhovanessian, Rafael Solana, Anis Larbi and Graham Pawelec

    Citation: Immunity & Ageing 2008 5:11

    Content type: Review

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  13. On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related diseases was held in Palermo, Italy. Here, the lecture of V. Nicita-Mauro on Smoking, health and ageing is summarized. Smoking represe...

    Authors: Vittorio Nicita-Mauro, Giorgio Basile, Giuseppe Maltese, Claudio Nicita-Mauro, Sebastiano Gangemi and Calogero Caruso

    Citation: Immunity & Ageing 2008 5:10

    Content type: Short report

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  14. During the past century, humans have gained more years of average life expectancy than in the last 10,000 years; we are now living in a rapidly ageing world. The sharp rise in life expectancy, coupled to a ste...

    Authors: Matteo Bulati, Mariavaleria Pellicanò, Sonya Vasto and Giuseppina Colonna-Romano

    Citation: Immunity & Ageing 2008 5:9

    Content type: Short report

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  16. On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related diseases was held in Palermo, Italy. Here, the lectures of M. Racchi on History and future perspectives of Alzheimer Biomarkers and of...

    Authors: Marco Racchi, Daniela Uberti, Stefano Govoni, Maurizio Memo, Cristina Lanni, Sonya Vasto, Giuseppina Candore, Calogero Caruso, Loriana Romeo and Giovanni Scapagnini

    Citation: Immunity & Ageing 2008 5:7

    Content type: Short report

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  17. T cell-mediated immunity in elderly people is compromised in ways reflected in the composition of the peripheral T cell pool. The advent of polychromatic flow cytometry has made analysis of cell subsets feasib...

    Authors: Sven Koch, Anis Larbi, Evelyna Derhovanessian, Dennis Özcelik, Elissaveta Naumova and Graham Pawelec

    Citation: Immunity & Ageing 2008 5:6

    Content type: Research

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  18. Chronic inflammation is a well-known corollary of the aging process and is believed to significantly contribute to morbidity and mortality of many age-associated chronic diseases. However, the mechanisms that ...

    Authors: Andres Kriete, Kelli L Mayo, Nirupama Yalamanchili, William Beggs, Patrick Bender, Csaba Kari and Ulrich Rodeck

    Citation: Immunity & Ageing 2008 5:5

    Content type: Research

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  19. Nitric oxide (NO) synthesized by endothelial nitric oxide synthase (eNOS) plays an important role in regulation of endothelial function and in the control of blood pressure. However, the results from some stud...

    Authors: Daniela Colomba, Giovanni Duro, Salvatore Corrao, Christiano Argano, Tiziana Di Chiara, Domenico Nuzzo, Federica Pizzo, Gaspare Parrinello, Rosario Scaglione and Giuseppe Licata

    Citation: Immunity & Ageing 2008 5:4

    Content type: Research

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  21. The safety and immunogenicity of an MF59™-adjuvanted subunit influenza vaccine (Sub/MF59™; FLUAD®, Novartis Vaccines) was evaluated among elderly Chinese subjects (≥ 60 years of age). After a preliminary Phase I,...

    Authors: Rongcheng Li, Hanhua Fang, Yanping Li, Youping Liu, Michele Pellegrini and Audino Podda

    Citation: Immunity & Ageing 2008 5:2

    Content type: Research

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  23. The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly peo...

    Authors: Richard Aspinall, Giuseppe Del Giudice, Rita B Effros, Beatrix Grubeck-Loebenstein and Suryaprakash Sambhara

    Citation: Immunity & Ageing 2007 4:9

    Content type: Review

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  24. The mechanism explaining the increased disease susceptibility in aging is not well understood. CD8+ T cells are crucial in anti-viral and anti-tumor responses. Although the chemokine system plays a critical ro...

    Authors: Raymond Yung, RuRan Mo, Annabelle Grolleau-Julius and Mark Hoeltzel

    Citation: Immunity & Ageing 2007 4:8

    Content type: Research

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  25. The capacity of the remodelling immune responses during stress (named immune plasticity) is fundamental to reach successful ageing. We herein report two pivotal experimental models in order to demonstrate the ...

    Authors: Eugenio Mocchegiani, Robertina Giacconi, Elisa Muti, Catia Cipriano, Laura Costarelli, Silvia Tesei, Nazzarena Gasparini and Marco Malavolta

    Citation: Immunity & Ageing 2007 4:7

    Content type: Short report

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  27. The importance of Zn for optimal functioning of the immune system and antioxidant stress response is well documented. Zn homeostasis influences development and function of immune cells, activity of stress-rela...

    Authors: Eugenio Mocchegiani

    Citation: Immunity & Ageing 2007 4:5

    Content type: Short report

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  28. On April 18, 2007 an international meeting on Pathophysiology of Ageing, Longevity and Age-Related Diseases was held in Palermo, Italy. Several interesting topics on Cancer, Immunosenescence, Age-related infla...

    Authors: Alexander Bürkle, Graziella Caselli, Claudio Franceschi, Erminia Mariani, Paolo Sansoni, Angela Santoni, Giancarlo Vecchio, Jacek M Witkowski and Calogero Caruso

    Citation: Immunity & Ageing 2007 4:4

    Content type: Review

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  29. Viral and bacterial infections have been considered as a risk factor for Coronary Heart Disease (CHD). NK cells, as a first line of defense against those infections, may play a role in CHD development. Thus, t...

    Authors: Łukasz Hak, Jolanta Myśliwska, Joanna Więckiewicz, Krzysztof Szyndler, Piotr Trzonkowski, Janusz Siebert and Andrzej Myśliwski

    Citation: Immunity & Ageing 2007 4:3

    Content type: Research

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  30. Ageing is associated with declines in many physiological parameters, including multiple immune system functions. The rate of acceleration of the frequency of death due to cardiovascular disease or cancer seems...

    Authors: Sonya Vasto, Giuseppina Colonna-Romano, Anis Larbi, Anders Wikby, Calogero Caruso and Graham Pawelec

    Citation: Immunity & Ageing 2007 4:2

    Content type: Review

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  31. We describe the inflammation pathway from Cholesterol to Aging. Interleukin 6 mediated inflammation is implicated in age-related disorders including Atherosclerosis, Peripheral Vascular Disease, Coronary Arter...

    Authors: Sota Omoigui

    Citation: Immunity & Ageing 2007 4:1

    Content type: Hypothesis

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  33. Cellular immunity plays a crucial role in cytomegalovirus (CMV) infection and substantial populations of CMV-specific T cells accumulate throughout life. However, although CMV infection occurs during childhood...

    Authors: Haruki Komatsu, Ayano Inui, Tsuyoshi Sogo, Tomoo Fujisawa, Hironori Nagasaka, Shigeaki Nonoyama, Sophie Sierro, John Northfield, Michaela Lucas, Anita Vargas and Paul Klenerman

    Citation: Immunity & Ageing 2006 3:11

    Content type: Research

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  35. a decline in immune and endocrine function occurs with aging. The main purpose of this study was to investigate the impact of long-term endurance training on the immune and endocrine system of elderly men. The...

    Authors: Milton Hideaki Arai, Alberto JS Duarte and Valéria Maria Natale

    Citation: Immunity & Ageing 2006 3:9

    Content type: Research

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  36. Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins catalysed by poly(ADP-ribose) polymerases (PARPs), using NAD+ as a substrate. Activation of PARP-1 is in immediate response to DNA da...

    Authors: Andrea Kunzmann, Dan Liu, Kathryn Annett, Muriel Malaisé, Bastian Thaa, Paul Hyland, Yvonne Barnett and Alexander Bürkle

    Citation: Immunity & Ageing 2006 3:8

    Content type: Methodology

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  37. An inexpensive Plexiglas apparatus which allows a simple and rapid preparation of horizontal polyacrylamide gels of different dimensions for different purposes, is described. Preparation of such gels is as eas...

    Authors: Vincenzo Izzo, Maria A Costa, Renata Di Fiore, Giovanni Duro, Daniele Bellavia, Eleonora Cascone, Paolo Colombo, Maria C Gioviale and Rainer Barbieri

    Citation: Immunity & Ageing 2006 3:7

    Content type: Methodology

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  38. The relevance of zinc for proper functioning of the entire immune system is already well documented. However, the identification of individuals who really need zinc supplementation is still debated in view of ...

    Authors: Eugenio Mocchegiani, Marco Malavolta, Fiorella Marcellini and Graham Pawelec

    Citation: Immunity & Ageing 2006 3:6

    Content type: Short report

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  39. Aging is associated with a paradox of immunodeficiency and inflammation (an evidence of hyperactive immune system). Apoptosis is associated with cellular depletion and suppression of inflammatory response. In ...

    Authors: Sudhir Gupta, Anshu Agrawal, Sudhanshu Agrawal, Houfen Su and Sastry Gollapudi

    Citation: Immunity & Ageing 2006 3:5

    Content type: Review

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  40. The functional changes associated with endothelial senescence may be involved in human aging and age-related vascular disorders. Since the inflammatory cytokine interleukin (IL-)1 inhibits endothelial growth, ...

    Authors: Massimo Mariotti, Sara Castiglioni, Daniela Bernardini and Jeanette AM Maier

    Citation: Immunity & Ageing 2006 3:4

    Content type: Research

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  41. The number of old and oldest old patients undergoing surgery of varying severity is increasing. Ageing is a process that changes the performances of most physiological systems and increases susceptibility to d...

    Authors: Gaetano Di Vita, Carmela Rita Balistreri, Francesco Arcoleo, Salvatore Buscemi, Enrico Cillari, Marcello Donati, Maria Garofalo, Florinda Listì, Maria Paola Grimaldi, Rosalia Patti and Giuseppina Candore

    Citation: Immunity & Ageing 2006 3:3

    Content type: Research

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  42. Longitudinal studies are defining progressive alterations to the immune system associated with increased mortality in the very elderly. Many of these changes are exacerbated by or even caused by chronic T cell...

    Authors: Sonya Vasto, Marco Malavolta and Graham Pawelec

    Citation: Immunity & Ageing 2006 3:2

    Content type: Short report

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  44. Aging is associated with a decline in immune function (immunosenescence), a situation known to correlate with increased incidence of cancer, infectious and degenerative diseases. Innate, cellular and humoral i...

    Authors: V Srinivasan, GJM Maestroni, DP Cardinali, AI Esquifino, SR Pandi Perumal and SC Miller

    Citation: Immunity & Ageing 2005 2:17

    Content type: Review

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  45. The problems associated with the ageing immune system and vaccination were discussed recently at an international workshop at the Jenner Institute for Vaccine Research, Compton, UK, 6–7 October, 2005. This is ...

    Authors: Graham Pawelec

    Citation: Immunity & Ageing 2005 2:16

    Content type: Commentary

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  47. Osteoporosis is a condition characterized by low bone mass and increased bone fragility, putting patients at risk of fractures, which are major causes of morbidity substantially in older people. Osteoporosis i...

    Authors: Lia Ginaldi, Maria Cristina Di Benedetto and Massimo De Martinis

    Citation: Immunity & Ageing 2005 2:14

    Content type: Short report

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  48. There is strong evidence that an individual's genetic background is an important predisposing factor to longevity. In the present study we analysed the frequency of HLA class I, class II, as well as the TNF-α ...

    Authors: Elena Soto-Vega, Yvonne Richaud-Patin and Luis Llorente

    Citation: Immunity & Ageing 2005 2:13

    Content type: Research

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  49. Human aging is associated with progressive decline in immune functions, increased frequency of infections. Among immune functions, a decline in T cell functions during aging predominates. In this review, we wi...

    Authors: Sudhir Gupta, Houfen Su, Ruifen Bi, Sudhanshu Agrawal and Sastry Gollapudi

    Citation: Immunity & Ageing 2005 2:12

    Content type: Review

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  50. A common feature of Alzheimer's disease (AD) pathology is the abundance of activated microglia in neuritic plaques containing amyloid-beta protein (Aβ) and associated molecules including heparan sulfate proteo...

    Authors: Simona Bussini, Lucia Meda, Elio Scarpini, Emilio Clementi, Giancarlo Conti, Marco Tiriticco, Nereo Bresolin and Pierluigi Baron

    Citation: Immunity & Ageing 2005 2:11

    Content type: Research

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