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  1. Content type: Research

    With ageing, long-standing inflammation can be destructive, contributing to development of several disorders, among these Alzheimer’s disease (AD). C-reactive protein (CRP) is a relatively stable peripheral in...

    Authors: Jessica Mira Gabin, Ingvild Saltvedt, Kristian Tambs and Jostein Holmen

    Citation: Immunity & Ageing 2018 15:4

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  3. Content type: Research

    Progressive T cell decline in aged humans is associated with a deficiency of naïve (TN) and central memory (TCM) T cells. We have previously reported increased Tumor necrosis factor-α (TNF-α)-induced apoptosis in...

    Authors: Sudhir Gupta, Houfen Su, Sudhanshu Agrawal and Sastry Gollapudi

    Citation: Immunity & Ageing 2018 15:2

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  4. Content type: Review

    Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hal...

    Authors: Giulia C. Leonardi, Giulia Accardi, Roberto Monastero, Ferdinando Nicoletti and Massimo Libra

    Citation: Immunity & Ageing 2018 15:1

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  5. Content type: Review

    A better hygiene, a Westernized diet, air pollution, climate changes, and other factors that influence host microbiota, a key player in the induction and maintenance of immunoregulatory circuits and tolerance,...

    Authors: Gabriele Di Lorenzo, Danilo Di Bona, Federica Belluzzo and Luigi Macchia

    Citation: Immunity & Ageing 2017 14:23

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  6. Content type: Research

    Individuals with a spinal cord injury (SCI), despite specialized rehabilitation and good health care, have a reduced life expectancy. Infectious diseases, such as pneumonias, infected pressure sores and urinar...

    Authors: David Pavlicek, Jörg Krebs, Simona Capossela, Alessandro Bertolo, Britta Engelhardt, Jürgen Pannek and Jivko Stoyanov

    Citation: Immunity & Ageing 2017 14:22

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  7. Content type: Review

    Aging is an agglomerate of biological long-lasting processes that result being inevitable. Main actors in this scenario are both long-term inflammation and oxidative stress. It has been proved that oxidative s...

    Authors: Marco Casciaro, Eleonora Di Salvo, Elisabetta Pace, Elvira Ventura-Spagnolo, Michele Navarra and Sebastiano Gangemi

    Citation: Immunity & Ageing 2017 14:21

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  8. Content type: Research

    It has recently been shown that the leukotriene receptor antagonist montelukast rejuvenates aged brains in rats. The question is whether this commonly used, systemic, anti-asthmatic medicine has a similar effe...

    Authors: Bjørn Grinde and Bo Engdahl

    Citation: Immunity & Ageing 2017 14:20

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  9. Content type: Letter to the Editor

    In an effort to understand the mechanisms underlying the high prevalence of gastrointestinal tract disorders in old age, we investigated the expression of intestinal antimicrobial peptides in the terminal smal...

    Authors: Sarah Tremblay, Nathalie Marie Louise Côté, Guillaume Grenier, Gabriella Duclos-Lasnier, Louis-Charles Fortier, Subburaj Ilangumaran and Alfredo Menendez

    Citation: Immunity & Ageing 2017 14:19

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  10. Content type: Research

    Neutrophil dysfunction plays a key role in the development of diseases characterized by inflammation and angiogenesis. Here, we studied the systemic expression of neutrophil markers reflecting activation, adhe...

    Authors: Marie Krogh Nielsen, Sven Magnus Hector, Kelly Allen, Yousif Subhi and Torben Lykke Sørensen

    Citation: Immunity & Ageing 2017 14:18

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  11. Content type: Research

    The age-related dysregulation of the immune system in older persons results in reduced responses to vaccination and greater susceptibility to infection, especially in frail individuals who suffer the greatest ...

    Authors: Jürgen M. Bauer, Antonio De Castro, Nabil Bosco, Celine Romagny, Rebecca Diekmann, Jalil Benyacoub and Karine Vidal

    Citation: Immunity & Ageing 2017 14:17

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  12. Content type: Short report

    Many currently used vaccines are less immunogenic in the elderly compared to young adults. The impact of latent infection with Cytomegalovirus (CMV) on vaccine-induced antibody responses has been discussed con...

    Authors: Birgit Weinberger, Michael Keller and Beatrix Grubeck-Loebenstein

    Citation: Immunity & Ageing 2017 14:16

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  13. Content type: Research

    CD4+ T cells can be broadly divided into naïve and memory subsets, each of which are differentially impaired by the aging process. It is unclear if and how these differences are reflected at the transcriptomic...

    Authors: Jackson Taylor, Lindsay Reynolds, Li Hou, Kurt Lohman, Wei Cui, Stephen Kritchevsky, Charles McCall and Yongmei Liu

    Citation: Immunity & Ageing 2017 14:15

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  14. Content type: Research

    Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T-cell system. Mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (E...

    Authors: Ling Huang, Nicolle H. R. Litjens, Nynke M. Kannegieter, Mariska Klepper, Carla C. Baan and Michiel G. H. Betjes

    Citation: Immunity & Ageing 2017 14:14

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  15. Content type: Research

    Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone re...

    Authors: Emanuela Galliera, Monica Gioia Marazzi, Carmine Gazzaruso, Pietro Gallotti, Adriana Coppola, Tiziana Montalcini, Arturo Pujia and Massimiliano M. Corsi Romanelli

    Citation: Immunity & Ageing 2017 14:13

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  16. Content type: Research

    Much evidence indicates receptor for advanced glycation end products (RAGE) related inflammation play essential roles during aging. However, the majority of studies have focused on advanced glycation end produ...

    Authors: Myeongjoo Son, Wook-Jin Chung, Seyeon Oh, Hyosang Ahn, Chang Hu Choi, Suntaek Hong, Kook Yang Park, Kuk Hui Son and Kyunghee Byun

    Citation: Immunity & Ageing 2017 14:12

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  17. Content type: Short report

    Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on ...

    Authors: Almudena Crooke, Juan Martínez-Henández, Joaquín Martínez-López, Alfonso Cruz-Jentoft, Fernando Huete-Toral and Jesús Pintor

    Citation: Immunity & Ageing 2017 14:11

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  18. Content type: Research

    Herpes viruses establish a life-long latency and can cause symptoms during both first-time infection and later reactivation. The aim of the present study was to describe the seroepidemiology of Herpes simplex ...

    Authors: Jan Olsson, Eloise Kok, Rolf Adolfsson, Hugo Lövheim and Fredrik Elgh

    Citation: Immunity & Ageing 2017 14:10

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  19. Content type: Research

    We have previously reported elevated expression of multiple pro-inflammatory markers in the lumbar spinal cord (LSC) of middle-aged male rats compared to young adults suggesting a para-inflammatory state devel...

    Authors: William Galbavy, Yong Lu, Martin Kaczocha, Michelino Puopolo, Lixin Liu and Mario J. Rebecchi

    Citation: Immunity & Ageing 2017 14:9

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  20. Content type: Research

    A preventative strategy for Respiratory Syncytial Virus (RSV) infection constitutes an under-recognized unmet medical need among older adults. Four formulations of a novel recombinant RSV F nanoparticle vaccin...

    Authors: Louis Fries, Vivek Shinde, Jeffrey J. Stoddard, D. Nigel Thomas, Eloi Kpamegan, Hanxin Lu, Gale Smith, Somia P. Hickman, Pedro Piedra and Gregory M. Glenn

    Citation: Immunity & Ageing 2017 14:8

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  21. Content type: Research

    An exercise-based Cardiac Rehabilitation Programme (CRP) is established as adjuvant therapy in heart failure (HF), nevertheless it is underutilized, especially in the elderly. While the functional and hemodyna...

    Authors: Giusy Russomanno, Graziamaria Corbi, Valentina Manzo, Nicola Ferrara, Giuseppe Rengo, Annibale A. Puca, Salvatore Latte, Albino Carrizzo, Maria Consiglia Calabrese, Ramaroson Andriantsitohaina, Walter Filippelli, Carmine Vecchione, Amelia Filippelli and Valeria Conti

    Citation: Immunity & Ageing 2017 14:7

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  22. Content type: Research

    The current concept of overweight/obesity is most likely related to a combination of increased caloric intake and decreased energy expenditure. Widespread inflammation, associated with both conditions, appears...

    Authors: Silvana Mara Turbino Luz Ribeiro, Laís Roquete Lopes, Guilherme de Paula Costa, Vivian Paulino Figueiredo, Deena Shrestha, Aline Priscila Batista, Roney Luiz de Carvalho Nicolato, Fernando Luiz Pereira de Oliveira, Juliana Assis Silva Gomes and Andre Talvani

    Citation: Immunity & Ageing 2017 14:6

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  23. Content type: Research

    Age-related changes of the immune system, termed immunosenescence, may underlie the increased risk of infections and morbidity in the elderly. Little is known about the effects of acute exercise on peripheral ...

    Authors: Kornelis S. M. van der Geest, Qi Wang, Thijs M. H. Eijsvogels, Hans J. P. Koenen, Irma Joosten, Elisabeth Brouwer, Maria T. E. Hopman, Joannes F. M. Jacobs and Annemieke M. H. Boots

    Citation: Immunity & Ageing 2017 14:5

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  25. Content type: Research

    NK cells are key effector lymphocytes of innate immunity provided with constitutive cytolytic activity, however, their role in human ageing is not entirely understood. The study aimed to analyze the expression...

    Authors: Lucyna Kaszubowska, Jerzy Foerster, Jan Jacek Kaczor, Daria Schetz, Tomasz Jerzy Ślebioda and Zbigniew Kmieć

    Citation: Immunity & Ageing 2017 14:3

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  26. Content type: Research

    Immunosenescence is associated with several changes in adaptive and innate immune cells. Altered cytokine production is among the most prominent of these changes. The impact of age-related alterations on cytok...

    Authors: Gabriela Silveira-Nunes, Elaine Speziali, Andréa Teixeira-Carvalho, Danielle M. Vitelli-Avelar, Renato Sathler-Avelar, Taciana Figueiredo-Soares, Maria Luiza Silva, Vanessa Peruhype-Magalhães, Daniel Gonçalves Chaves, Gustavo Eustáquio Brito-Melo, Glenda Meira Cardoso, Eric Bassetti Soares, Silvana Maria Elói-Santos, Rosângela Teixeira, Dulciene Magalhães Queiroz, Rodrigo Corrêa-Oliveira…

    Citation: Immunity & Ageing 2017 14:2

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  27. Content type: Research

    Magnesium (Mg) and calcium (Ca) are the principal essential elements involved in endothelial cell homeostasis. Extracellular changes in the levels of either alter endothelial contraction and dilatation. Conseq...

    Authors: E. Vianello, E. Dozio, A. Barassi, G. Sammarco, L. Tacchini, M. M. Marrocco-Trischitta, S. Trimarchi and M. M. Corsi Romanelli

    Citation: Immunity & Ageing 2017 14:1

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  28. Content type: Research

    Upregulation of pro-inflammatory cytokines has not only been associated with increased morbidity and mortality in older adults but also has been linked to frailty. In the current study we aimed to compare the ...

    Authors: P. Van Epps, D. Oswald, P. A. Higgins, T. R. Hornick, H. Aung, R. E. Banks, B. M. Wilson, C. Burant, S. Gravenstein and D. H. Canaday

    Citation: Immunity & Ageing 2016 13:27

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    The Erratum to this article has been published in Immunity & Ageing 2017 14:4

  29. Content type: Short report

    We have recently demonstrated that single shot vaccinations against tetanus and diphtheria do not lead to long-lasting immunity against diphtheria in elderly persons despite administration at 5 year intervals....

    Authors: Marco Grasse, Andreas Meryk, Michael Schirmer, Beatrix Grubeck-Loebenstein and Birgit Weinberger

    Citation: Immunity & Ageing 2016 13:26

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  30. Content type: Review

    The acute phase protein Pentraxin 3 (PTX3) plays a non-redundant role as a soluble pattern recognition receptor for selected pathogens and it represents a rapid biomarker for primary local activation of innate...

    Authors: Francesco Fornai, Albino Carrizzo, Maurizio Forte, Mariateresa Ambrosio, Antonio Damato, Michela Ferrucci, Francesca Biagioni, Carla Busceti, Annibale A. Puca and Carmine Vecchione

    Citation: Immunity & Ageing 2016 13:25

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  31. Content type: Research

    Alterations in the number and composition of lymphocytes and their subsets in blood are considered a hallmark of immune system aging. However, it is unknown whether the rates of change of lymphocytes are stabl...

    Authors: Yun Lin, Jiewan Kim, E. Jeffrey Metter, Huy Nguyen, Thai Truong, Ana Lustig, Luigi Ferrucci and Nan-ping Weng

    Citation: Immunity & Ageing 2016 13:24

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  32. Content type: Research

    There has been a recent upsurge of interest in complementary medicine, especially dietary supplements and foods functional in delaying the onset of age-associated neurodegenerative diseases. Mushrooms have lon...

    Authors: A. Trovato, R. Siracusa, R. Di Paola, M. Scuto, M. L. Ontario, Ornella Bua, Paola Di Mauro, M. A. Toscano, C. C. T. Petralia, L. Maiolino, A. Serra, S. Cuzzocrea and Vittorio Calabrese

    Citation: Immunity & Ageing 2016 13:23

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  33. Content type: Research

    Ageing, inactivity and obesity are associated with chronic low-grade inflammation contributing to a variety of lifestyle-related diseases. Transforming growth factor-β (TGF-β) is a multimodal protein with vari...

    Authors: Barbara Schober-Halper, Marlene Hofmann, Stefan Oesen, Bernhard Franzke, Thomas Wolf, Eva-Maria Strasser, Norbert Bachl, Michael Quittan, Karl-Heinz Wagner and Barbara Wessner

    Citation: Immunity & Ageing 2016 13:22

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  34. Content type: Research

    In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for the development of aging-related diseases and frailty. Using data from several thousand Eastern Europeans aged 65 years and ol...

    Authors: Monika Puzianowska-Kuźnicka, Magdalena Owczarz, Katarzyna Wieczorowska-Tobis, Pawel Nadrowski, Jerzy Chudek, Przemyslaw Slusarczyk, Anna Skalska, Marta Jonas, Edward Franek and Malgorzata Mossakowska

    Citation: Immunity & Ageing 2016 13:21

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  35. Content type: Research

    Ischemic injury triggers inflammatory cascades and changes in the protein synthesis, neurotransmitters and neuro-hormones in the brain parenchyma that may further amplify the tissue damage. The “Triage® Stroke...

    Authors: Francesco Iemolo, Enzo Sanzaro, Giovanni Duro, Antonello Giordano and Maurizio Paciaroni

    Citation: Immunity & Ageing 2016 13:19

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  36. Content type: Research

    Over the past fifteen years, we have demonstrated that cortisol and dehydroepiandrosterone (DHEA) have opposite effects on the regulation of protein kinase C (PKC) activity in the context of the immune system....

    Authors: Emanuela Corsini, Valentina Galbiati, Angela Papale, Elena Kummer, Antonella Pinto, Melania M. Serafini, Antonio Guaita, Roberto Spezzano, Donatella Caruso, Marina Marinovich and Marco Racchi

    Citation: Immunity & Ageing 2016 13:20

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  37. Content type: Editorial

    During the last two centuries the average lifespan has increased at a rate of approximately 3 months/year in both sexes, hence oldest old people are becoming the population with the fastest growth in Western W...

    Authors: Anna Aiello, Giulia Accardi, Giuseppina Candore, Giuseppe Carruba, Sergio Davinelli, Giuseppe Passarino, Giovanni Scapagnini, Sonya Vasto and Calogero Caruso

    Citation: Immunity & Ageing 2016 13:17

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  38. Content type: Research

    Chronic upper respiratory tract infections (cURTI) are very frequent illnesses which occur at any age of life. In elderly, cURTI are complicated by immunosenescence, with involvement of lung immune responsiven...

    Authors: Thea Magrone, Mauro Galantino, Nunzio Di Bitonto, Luisella Borraccino, Gerardo Chiaromonte and Emilio Jirillo

    Citation: Immunity & Ageing 2016 13:18

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  39. Content type: Research

    Molecular and genetic studies in model organisms have recently revealed a dynamic interplay between immunity and ageing mechanisms. In the fruit fly Drosophila melanogaster, inhibition of the insulin/insulin-like...

    Authors: Sarah McCormack, Shruti Yadav, Upasana Shokal, Eric Kenney, Dustin Cooper and Ioannis Eleftherianos

    Citation: Immunity & Ageing 2016 13:15

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  40. Content type: Review

    An extensive literature describes the positive impact of dietary phytochemicals on overall health and longevity. Dietary phytochemicals include a large group of non-nutrients compounds from a wide range of pla...

    Authors: Sergio Davinelli, Michael Maes, Graziamaria Corbi, Armando Zarrelli, Donald Craig Willcox and Giovanni Scapagnini

    Citation: Immunity & Ageing 2016 13:16

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  41. Content type: Research

    It is well known that Mediterranean Diet can positively influence the health of each individual, in particular it is know that fibers have an important role. However, in Mediterranean cities most people do not...

    Authors: Annalisa Barera, Silvio Buscemi, Roberto Monastero, Calogero Caruso, Rosalia Caldarella, Marcello Ciaccio and Sonya Vasto

    Citation: Immunity & Ageing 2016 13:14

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  42. Content type: Review

    There is convincing epidemiological and clinical evidence that, independent of aging, lifestyle and, notably, nutrition are associated with development or progression of major human cancers, including breast, ...

    Authors: Giuseppe Carruba, Letizia Cocciadiferro, Antonietta Di Cristina, Orazia M. Granata, Cecilia Dolcemascolo, Ildegarda Campisi, Maurizio Zarcone, Maria Cinquegrani and Adele Traina

    Citation: Immunity & Ageing 2016 13:13

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  43. Content type: Review

    Healthy aging and longevity in humans are modulated by a lucky combination of genetic and non-genetic factors. Family studies demonstrated that about 25 % of the variation in human longevity is due to genetic ...

    Authors: Giuseppe Passarino, Francesco De Rango and Alberto Montesanto

    Citation: Immunity & Ageing 2016 13:12

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  44. Content type: Research

    The aim of this study was to analyse the nutraceutical properties of table green olives Nocellara del Belice, a traditional Mediterranean food. The Mediterranean Diet has as key elements olives and extra virgin o...

    Authors: Giulia Accardi, Anna Aiello, Valeria Gargano, Caterina Maria Gambino, Santo Caracappa, Sandra Marineo, Gesualdo Vesco, Ciriaco Carru, Angelo Zinellu, Maurizio Zarcone, Calogero Caruso and Giuseppina Candore

    Citation: Immunity & Ageing 2016 13:11

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  45. Content type: Research

    Injecting drug users (IDU) are at premature risk of developing multimorbidity and mortality from causes commonly observed in the elderly. Ageing of the immune system (immune-senescence) can lead to premature m...

    Authors: Bart P. X. Grady, Nening M. Nanlohy and Debbie van Baarle

    Citation: Immunity & Ageing 2016 13:10

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  46. Content type: Research

    Acute aortic dissection (AAD) is an event which may be rapidly fatal without early diagnosis and treatment. Aging is one of the main risk factors that could leading to AAD. To date, no specific biomarkers are ...

    Authors: E. Vianello, E. Dozio, R. Rigolini, M. M. Marrocco-Trischitta, L. Tacchini, S. Trimarchi and M. M. Corsi Romanelli

    Citation: Immunity & Ageing 2016 13:9

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  47. Content type: Short report

    Recently, phage display technology has made it possible to define the circulating repertoire of humoral immunity. This study was designed to define the circulating antibodies specific to centenarians.

    Authors: Jungwon Han, So-Hyun Park, Dong-Jo Kim, Hyori Kim, Yoon-Ho Choi, Jong-Hyuk Lee, Sang Chul Park and Junho Chung

    Citation: Immunity & Ageing 2016 13:8

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  48. Content type: Research

    To investigate mechanisms that determine healthy aging is of major interest in the modern world marked by longer life expectancies. In addition to lifestyle and environmental factors genetic factors also play ...

    Authors: Lutz Hamann, Jasmin Bustami, Leonid Iakoubov, Malgorzata Szwed, Malgorzata Mossakowska, Ralf R. Schumann and Monika Puzianowska-Kuznicka

    Citation: Immunity & Ageing 2016 13:7

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  49. Content type: Research

    Ageing increases risk of respiratory infections and impairs the response to influenza vaccination. Pre- and probiotics offer an opportunity to modulate anti-viral defenses and the response to vaccination via a...

    Authors: Agnieszka Przemska-Kosicka, Caroline E. Childs, Sumia Enani, Catherine Maidens, Honglin Dong, Iman Bin Dayel, Kieran Tuohy, Susan Todd, Margot A. Gosney and Parveen Yaqoob

    Citation: Immunity & Ageing 2016 13:6

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  50. Content type: Research

    Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Mea...

    Authors: Shu-Chun Chuang, Heiner Boeing, Stein Emil Vollset, Øivind Midttun, Per Magne Ueland, Bas Bueno-de-Mesquita, Martin Lajous, Guy Fagherazzi, Marie-Christine Boutron-Ruault, Rudolf Kaaks, Tilman Küehn, Tobias Pischon, Dagmar Drogan, Anne Tjønneland, Kim Overvad, J Ramón Quirós…

    Citation: Immunity & Ageing 2016 13:5

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Immunity & Ageing

ISSN: 1742-4933

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