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  1. Traumatic brain injury (TBI) is a leading cause of death and long-term disability worldwide. In addition to primary brain damage, systemic immune alterations occur, with evidence for dysregulated immune respon...

    Authors: Marta Magatti, Francesca Pischiutta, Fabrizio Ortolano, Anna Pasotti, Enrico Caruso, Anna Cargnoni, Andrea Papait, Franco Capuzzi, Tommaso Zoerle, Marco Carbonara, Nino Stocchetti, Stefano Borsa, Marco Locatelli, Elisa Erba, Daniele Prati, Antonietta R Silini…
    Citation: Immunity & Ageing 2023 20:41
  2. Lower respiratory infections are a leading cause of severe morbidity and mortality among older adults. Despite ubiquitous exposure to common respiratory pathogens throughout life and near universal seropositiv...

    Authors: Olivia B. Parks, Taylor Eddens, Jorna Sojati, Jie Lan, Yu Zhang, Tim D. Oury, Manda Ramsey, John J. Erickson, Craig A. Byersdorfer and John V. Williams
    Citation: Immunity & Ageing 2023 20:40
  3. More and more evidences are proving that microglia play a crucial role in the pathogenesis of Alzheimer’s disease (AD) and the plasma Aβ1-42 levels significantly increased 15 years before the onset of dominantly ...

    Authors: Chunrong Li, Kangding Liu, Jie Zhu and Feiqi Zhu
    Citation: Immunity & Ageing 2023 20:39
  4. Seasonal influenza causes significant morbidity and mortality with a disproportionately high disease burden in older adults. Strain-specific hemagglutination-inhibition (HAI) antibody titer is a well-establish...

    Authors: Bettina Wunderlich, Thomas Laskow, Huifen Li, Li Zhang, Engle Abrams, Jing Tian, Jun Yu, Yiyin Chen, Juliette Tavenier, Yushu Huang, Kawsar Talaat, Jay H. Bream, Qian-Li Xue, Graham Pawelec and Sean X. Leng
    Citation: Immunity & Ageing 2023 20:38
  5. Older adults are more vulnerable to seasonal influenza than younger adults. The immune responses of older persons to the influenza vaccine are usually poorer than those of young individuals, which is hypothesi...

    Authors: Tongling Xiao, Miaomiao Wei, Xiaokun Guo, Yu Zhang, Zhongyan Wang, Xiaoshuang Xia, Xuemei Qi, Lin Wang, Xin Li and Sean X. Leng
    Citation: Immunity & Ageing 2023 20:37
  6. Evidence has linked self-reported sedentary behavior (SB) and physical activity (PA) with cognitive impairment; however, the underlying mechanisms are poorly understood. We examined the associations of the acc...

    Authors: Yongxiang Wang, Qi Han, Xiaolei Han, Yi Dong, Ming Mao, Chaoqun Wang, Xiaojie Wang, Shi Tang, Cuicui Liu, Yuanjing Li, Tingting Hou, Lin Cong, Yifeng Du and Chengxuan Qiu
    Citation: Immunity & Ageing 2023 20:36
  7. Immune function in the genital mucosa balances reproduction with protection against pathogens. As women age, genital infections, and gynecological cancer risk increase, however, the mechanisms that regulate ce...

    Authors: Siddharth Parthasarathy, Zheng Shen, Francisco J. Carrillo-Salinas, Vidya Iyer, Alison Vogell, Diego Illanes, Charles R. Wira and Marta Rodriguez-Garcia
    Citation: Immunity & Ageing 2023 20:34
  8. Frailty is an intermediate and reversible geriatric syndrome that often precedes dependence. Therefore, its identification is essential to prevent dependence. Several molecules have been proposed as biomarkers...

    Authors: Leire Iparraguirre, Ainhoa Alberro, Saioa GS Iñiguez, Maider Muñoz-Culla, Itziar Vergara, Ander Matheu and David Otaegui
    Citation: Immunity & Ageing 2023 20:33
  9. Since the beginning of SARS-CoV2 pandemic, the mortality rate among elderly patients (60–90 years) has been around 50%, so age has been a determining factor of a worse COVID-19 prognosis. Associated with age, ...

    Authors: M. S. Espinar-Buitrago, L. Tarancon-Diez, E. Vazquez-Alejo, E. Magro-Lopez, M. Genebat, F. Romero-Candau, M. Leal and M. A. Muñoz-Fernandez
    Citation: Immunity & Ageing 2023 20:32
  10. Human aging is characterized by a state of chronic inflammation, termed inflammaging, for which the causes are incompletely understood. It is known, however, that macrophages play a driving role in establishin...

    Authors: Alexandre Poirier, Chenyue Wu, Ana Maria Hincapie, Zuzet Martinez-Cordova, Belma Melda Abidin and Michel L. Tremblay
    Citation: Immunity & Ageing 2023 20:31
  11. Adjuvanted inactivated influenza vaccine (aIIV) and high-dose inactivated influenza vaccine (HD-IIV) are U.S.-licensed for adults aged ≥ 65 years. This study compared serum hemagglutination inhibition (HAI) an...

    Authors: Kenneth E. Schmader, Christine K. Liu, Brendan Flannery, Wes Rountree, Heidi Auerbach, Elizabeth D. Barnett, Elizabeth P. Schlaudecker, Christopher A. Todd, Marek Poniewierski, Mary A. Staat, Theresa Harrington, Rongxia Li, Karen R. Broder and Emmanuel B. Walter
    Citation: Immunity & Ageing 2023 20:30
  12. Progressive age-associated change in frequencies and functional capacities of immune cells is known as immunosenescence. Despite data linking chronic environmental, physiological, and psychosocial stressors wi...

    Authors: Ryan G. Snodgrass, Xiaowen Jiang, Charles B. Stephensen and Kevin D. Laugero
    Citation: Immunity & Ageing 2023 20:29
  13. Age-associated impairments of immune response and inflammaging likely contribute to poor vaccine efficacy. An appropriate balance between activation of immune memory and inflammatory response may be more effec...

    Authors: Kathleen A. Ross, April M. Tingle, Sujata Senapati, Kaitlyn G. Holden, Michael J. Wannemuehler, Surya K. Mallapragada, Balaji Narasimhan and Marian L. Kohut
    Citation: Immunity & Ageing 2023 20:28
  14. TDP-43 is an important DNA/RNA-binding protein that is associated with age-related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); however, its pathome...

    Authors: Wenkai Yue, Xue Deng, Zhao Wang, Mingsheng Jiang, Rirong Hu, Yongjia Duan, Qiangqiang Wang, Jihong Cui and Yanshan Fang
    Citation: Immunity & Ageing 2023 20:27
  15. Various autoimmune responses increase with age, but the underlying mechanism is not clear. In this study, we used CD4+ T cells expressing a transgenic T cell receptor specific for desmoglein 3 (Dsg3), which is th...

    Authors: Hisato Iriki, Miho Mukai, Yasuhiko Asahina, Yoko Kubo, Hiromi Ito, Masayuki Amagai and Hayato Takahashi
    Citation: Immunity & Ageing 2023 20:26
  16. Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psychological, behavioral, and social processes. Aging entails changes in the immune system ...

    Authors: Danay Saavedra, Ana Laura Añé-Kourí, Nir Barzilai, Calogero Caruso, Kyung-Hyun Cho, Luigi Fontana, Claudio Franceschi, Daniela Frasca, Nuris Ledón, Laura J. Niedernhofer, Karla Pereira, Paul D. Robbins, Alexa Silva, Gisela M. Suarez, Wim Vanden Berghe, Thomas von Zglinicki…
    Citation: Immunity & Ageing 2023 20:25
  17. Dementia and frailty are common age-related syndromes often linked to chronic inflammation. Identifying the biological factors and pathways that contribute to chronic inflammation is crucial for developing new...

    Authors: Lolita S. Nidadavolu, Danielle Feger, Diefei Chen, Yuqiong Wu, Francine Grodstein, Alden L. Gross, David A. Bennett, Jeremy D. Walston, Esther S. Oh and Peter M. Abadir
    Citation: Immunity & Ageing 2023 20:24
  18. Pain in Fabry disease (FD) is generally accepted to result from neuronal damage in the peripheral nervous system as a consequence of excess lipid storage caused by alpha-galactosidase A (α-Gal A) deficiency. S...

    Authors: Jeiny Luna Choconta, Verena Labi, Cristiana Dumbraveanu, Theodora Kalpachidou, Kai K. Kummer and Michaela Kress
    Citation: Immunity & Ageing 2023 20:22
  19. Morphological and functional alterations in aging reproductive organs result in decreased male fertility. The epididymis functions as the transition region for post-testicular sperm maturation. And we have pre...

    Authors: Jintao Zhuang, Xiangping Li, Jiahui Yao, Xiangzhou Sun, Jiumin Liu, Hua Nie, Yang Hu, Xiangan Tu, Huang Liu, Weibing Qin and Yun Xie
    Citation: Immunity & Ageing 2023 20:21
  20. Current influenza vaccines deliver satisfactory results in young people but are less effective in the elderly. Development of vaccines for an ever-increasing aging population has been an arduous challenge due ...

    Authors: Bo Ryoung Park, Ramireddy Bommireddy, David Hyunjung Chung, Ki-Hye Kim, Jeeva Subbiah, Yu-Jin Jung, Noopur Bhatnagar, Christopher D. Pack, Sampath Ramachandiran, Shaker J.C. Reddy, Periasamy Selvaraj and Sang-Moo Kang
    Citation: Immunity & Ageing 2023 20:20
  21. Age-related accumulation of highly differentiated CD8+ effector memory re-expressing CD45RA (EMRA) T-cells and disruption of the kynurenine (KYN) pathway are associated with chronic inflammation and the developme...

    Authors: Tim Konstantin Boßlau, Paulina Wasserfurth, Thomas Reichel, Christopher Weyh, Jana Palmowski, Josefine Nebl, Niklas Joisten, Sergen Belen, Alexander Schenk, Andreas Hahn, Philipp Zimmer and Karsten Krüger
    Citation: Immunity & Ageing 2023 20:19
  22. Aging is associated with progressive declines in immune responses leading to increased risk of severe infection and diminished vaccination responses. Influenza (flu) is a leading killer of older adults despite...

    Authors: Dominique E. Martin, Andreia N. Cadar, Hunter Panier, Blake L. Torrance, George A. Kuchel and Jenna M. Bartley
    Citation: Immunity & Ageing 2023 20:18
  23. Advanced age is one of the significant risk determinants for coronavirus disease 2019 (COVID-19)-related mortality and for long COVID complications. The contributing factors may include the age-related dynamic...

    Authors: Ludmila Müller and Svetlana Di Benedetto
    Citation: Immunity & Ageing 2023 20:17
  24. Immunosenescence is a complex process characterized by an age-related remodelling of immune system. The prominent effects of the immunosenescence process is the thymic involution and, consequently, the decreas...

    Authors: Ersilia Paparazzo, Silvana Geracitano, Vincenzo Lagani, Luigi Citrigno, Denise Bartolomeo, Mirella Aurora Aceto, Francesco Bruno, Raffaele Maletta, Giuseppe Passarino and Alberto Montesanto
    Citation: Immunity & Ageing 2023 20:16
  25. A wide spectrum of changes occurs in the brain with age, from molecular to morphological aspects, and inflammation accompanied by mitochondria dysfunction is one of the significant factors associated with age....

    Authors: Kaiwu He, Lulin Nie, Tahir Ali, Zizhen Liu, Weifen Li, Ruyan Gao, Zena Zhang, Jianjun Liu, Zhongliang Dai, Yongmei Xie, Zaijun Zhang, Gongping Liu, Ming Dong, Zhi-Jian Yu, Shupeng Li and Xifei Yang
    Citation: Immunity & Ageing 2023 20:15
  26. Natural antibodies (nAbs) against aggregation-prone proteins have been found in healthy normal subjects. These proteins likely have a pathogenetic role in neurodegenerative diseases of ageing. They include the...

    Authors: Roberto Paganelli, Alessia Paganelli, Graham Pawelec and Angelo Di Iorio
    Citation: Immunity & Ageing 2023 20:13
  27. Glycyrrhizic acid (GA), a saponin compound often used as a flavoring agent, can elicit anti-inflammatory and anti-tumor effects, and alleviate aging. However, the specific mechanism by which GA alters immune c...

    Authors: Xue Gong, Haitao Shen, Liuling Guo, Ce Huang, Tingting Su, Hao Wang, Shengyu Feng, Shanshan Yang, Fenjiao Huo, Haifeng Liu, Jianbo Zhu, Jian-Kang Zhu, Hongbin Li and Hailiang Liu
    Citation: Immunity & Ageing 2023 20:12
  28. The progressive deregulation of the immune system with age, termed immunosenescence, has been well studied in mammalian systems, but studies of immune function in long-lived, wild, non-mammalian populations ar...

    Authors: Anne M. Bronikowski, Ashley R. Hedrick, Greta A. Kutz, Kaitlyn G. Holden, Beth Reinke and John B. Iverson
    Citation: Immunity & Ageing 2023 20:11
  29. The loss in age-related immunological markers, known as immunosenescence, is caused by a combination of factors, one of which is inflammaging. Inflammaging is associated with the continuous basal generation of...

    Authors: Ananya Ananya, Kaitlyn G. Holden, Zhiling Gu, Dan Nettleton, Surya K. Mallapragada, Michael J. Wannemuehler, Marian L. Kohut and Balaji Narasimhan
    Citation: Immunity & Ageing 2023 20:10
  30. Older people achieve lower levels of antibody titers than younger populations after Covid-19 vaccination and show a marked waning humoral immunity over time, likely due to the senescence of the immune system. ...

    Authors: María del Mar Pozo-Balado, Ángel Bulnes-Ramos, Israel Olivas-Martínez, Vanesa Garrido-Rodríguez, Carmen Lozano, Ana I. Álvarez-Ríos, Berta Sánchez-Sánchez, Encarnación Sánchez-Bejarano, Isabel Maldonado-Calzado, José Manuel Martín-Lara, Juan Antonio Santamaría, Rafael Bernal, María Francisca González-Escribano, Manuel Leal and Yolanda M. Pacheco
    Citation: Immunity & Ageing 2023 20:9
  31. Chronic kidney disease (CKD) is age-related disease, and decreased renal function is associated with the premature aging of T cells and increased incidence of other age-related diseases. However, the relations...

    Authors: Kenichiro Iio, Daijiro Kabata, Rei Iio, Shinichi Shibamoto, Yuuki Watanabe, Masashi Morita, Yosuke Imai, Masaki Hatanaka, Hiroki Omori and Yoshitaka Isaka
    Citation: Immunity & Ageing 2023 20:8
  32. Chronic, low-grade inflammation, also termed ‘inflammaging’, has been linked to the development of some aging-associated disorders. Recent studies suggest that inflammaging is attributable to aging-associated ...

    Authors: Bin Yang, Chengzhi Lv, Li Ye, Zhen Wang, Yoon Kim, Wenhai Luo, Peter M. Elias and Mao-Qiang Man
    Citation: Immunity & Ageing 2023 20:7
  33. Frailty, a clinical syndrome commencing at midlife, is a risk for morbidity and mortality. Little is known about the factors that contribute to the chronic inflammatory state associated with frailty. Extracell...

    Authors: Anjali M. Byappanahalli, Nicole Noren Hooten, Mya Vannoy, Nicolle A. Mode, Ngozi Ezike, Alan B. Zonderman and Michele K. Evans
    Citation: Immunity & Ageing 2023 20:6
  34. There is increasing concern that cancer and cancer treatment accelerate aging and the associated cognitive decline. We showed recently that treatment of 9-month-old male mice with cisplatin causes cognitive de...

    Authors: Miriam Zamorano, Jenolyn F. Alexander, Desiree Catania, Shruti Dharmaraj, Annemieke Kavelaars and Cobi J. Heijnen
    Citation: Immunity & Ageing 2023 20:5
  35. Immune responses to COVID-19 mRNA vaccines have not been well characterized in frail older adults. We postulated that frailty is associated with impaired antibody and cellular mRNA vaccine responses.

    Authors: Charles T. Semelka, Michael E. DeWitt, Maria W. Blevins, Beth C. Holbrook, John W. Sanders and Martha A. Alexander-Miller
    Citation: Immunity & Ageing 2023 20:4
  36. The diffuse distribution of nicotinic cholinergic receptors (nAChRs) in both brain and peripheral immune cells points out their involvement in several pathological conditions. Indeed, the deregulated function ...

    Authors: E. Costantini, C. Carrarini, P. Borrelli, M. De Rosa, D. Calisi, S. Consoli, D. D’Ardes, F. Cipollone, M. Di Nicola, M. Onofrj, M. Reale and L. Bonanni
    Citation: Immunity & Ageing 2023 20:3
  37. The equine population in the United States and worldwide now includes a higher percentage of geriatric horses than ever previously recorded, and as methods to treat and manage elderly equids are developed and ...

    Authors: Sally DeNotta and Dianne McFarlane
    Citation: Immunity & Ageing 2023 20:2
  38. Diet and chronic inflammation might play a major role in the pathogenesis of mild cognitive impairment (MCI). In addition, peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mt...

    Authors: Qian Liu, Zhenshu Li, Ling Huang, Dezheng Zhou, Jingzhu Fu, Huilian Duan, Zehao Wang, Tong Yang, Jing Zhao, Wen Li, Huan Liu, Fei Ma, Changqing Sun, Guangshun Wang, Yue Du, Meilin Zhang…
    Citation: Immunity & Ageing 2023 20:1
  39. Obesity rates are increasing worldwide. Obesity leads to many complications, including predisposing individuals to the development of cognitive impairment as they age. Immune dysregulation, including inflammag...

    Authors: Rosemary E. Henn, Sarah E. Elzinga, Emily Glass, Rachel Parent, Kai Guo, Adam A. Allouch, Faye E. Mendelson, John Hayes, Ian Webber-Davis, Geoffery G. Murphy, Junguk Hur and Eva L. Feldman
    Citation: Immunity & Ageing 2022 19:67
  40. CD8+ T cells play an important role in host defense against infections and malignancies as well as contribute to the development of inflammatory disorders. Alterations in the frequency of naïve and memory CD8+ T ...

    Authors: Min Sun Shin, Hong-Jai Park, Juan Young and Insoo Kang
    Citation: Immunity & Ageing 2022 19:66
  41. The risk for symptomatic COVID-19 requiring hospitalization is higher in the older population. The course of the disease in hospitalised older patients may show significant variation, from mild to severe illne...

    Authors: M. Cardelli, E. Pierpaoli, F. Marchegiani, F. Marcheselli, F. Piacenza, R. Giacconi, R. Recchioni, T. Casoli, P. Stripoli, M. Provinciali, G. Matacchione, A. Giuliani, D. Ramini, J. Sabbatinelli, M. Bonafè, M. Di Rosa…
    Citation: Immunity & Ageing 2022 19:65
  42. Obesity is characterized by an elevated amount of fat and energy storage in the adipose tissue (AT) and is believed to be the root cause of many metabolic diseases (MDs). Obesity is associated with low-grade c...

    Authors: Ahmed Rakib, Sonia Kiran, Mousumi Mandal and Udai P. Singh
    Citation: Immunity & Ageing 2022 19:64
  43. It has been widely accepted that monocytes are one of the central mediators contributing to inflammaging. However, it remains unclear whether aged monocytes, similar to aged T cells, have characteristics of hy...

    Authors: Yu Cao, Yang Fan, Fangyuan Li, Yu Hao, Yaxian Kong, Chen Chen, Xing Hao, Dannuo Han, Guoli Li, Zengtao Wang, Chuan Song, Junyan Han and Hui Zeng
    Citation: Immunity & Ageing 2022 19:63
  44. Systemic chronic inflammation occurs with age. The association of the leukocyte mitochondrial DNA copy number, a measure of mitochondrial function in aging, with the temporal profile of serum high-sensitivity ...

    Authors: I-Chien Wu, Chin-San Liu, Wen-Ling Cheng, Ta-Tsung Lin, Hui-Ling Chen, Pei-Fen Chen, Ray-Chin Wu, Chen-Wei Huang, Chao A. Hsiung and Chih-Cheng Hsu
    Citation: Immunity & Ageing 2022 19:62
  45. Authors: Mateus V. de Castro, Monize V. R. Silva, Michel S. Naslavsky, Marilia O. Scliar, Kelly Nunes, Maria Rita Passos-Bueno, Erick C. Castelli, Jhosiene Y. Magawa, Flávia L. Adami, Ana I. S. Moretti, Vivian L. de Oliveira, Silvia B. Boscardin, Edecio Cunha-Neto, Jorge Kalil, Emmanuelle Jouanguy, Paul Bastard…
    Citation: Immunity & Ageing 2022 19:61

    The original article was published in Immunity & Ageing 2022 19:57

  46. Traumatic injury elicits a hyperinflammatory response and remodelling of the immune system leading to immuneparesis. This study aimed to evaluate whether traumatic injury results in a state of prematurely aged...

    Authors: Mark A. Foster, Conor Bentley, Jon Hazeldine, Animesh Acharjee, Ornit Nahman, Shai S. Shen-Orr, Janet M. Lord and Niharika A. Duggal
    Citation: Immunity & Ageing 2022 19:60
  47. The sequestering of oxidation-modified low-density lipoprotein by macrophages results in the accumulation of fatty deposits within the walls of arteries. Necrosis of these cells causes a release of intercellul...

    Authors: Joshua A. Taylor, Mark A. Hutchinson, Patricia J. Gearhart and Robert W. Maul
    Citation: Immunity & Ageing 2022 19:59

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