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  1. Aging is accompanied by a dramatic decline in the interleukin (IL)-2 production capacity of human immune cells, thus making seniors more susceptible to a variety of age-related diseases. A common cause of impa...

    Authors: Bastian Robinson Baarz, Thea Laurentius, Jana Wolf, Inga Wessels, Leo Cornelius Bollheimer and Lothar Rink
    Citation: Immunity & Ageing 2022 19:40
  2. Biological aging represents a loss of integrity and functionality of physiological systems over time. While associated with an enhanced risk of adverse outcomes such as hospitalization, disability and death fo...

    Authors: Chris P. Verschoor, Daniel W. Belsky, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, Janet E. McElhaney and George A. Kuchel
    Citation: Immunity & Ageing 2022 19:39
  3. Age and comorbidity are the main determinants of COVID-19 outcome. Shorter leukocyte telomere length (TL), a hallmark of biological aging, has been associated with worse COVID-19 outcomes. We sought to determi...

    Authors: Miriam Retuerto, Ana Lledó, Beatriz Fernandez-Varas, Rosa Guerrero-López, Alicia Usategui, Antonio Lalueza, Rocío García-García, Esther Mancebo, Estela Paz-Artal, Leandro Sastre, Rosario Perona and José L. Pablos
    Citation: Immunity & Ageing 2022 19:38
  4. Traditionally, the immune system is understood to be divided into discrete cell types that are identified via surface markers. While some cell type distinctions are no doubt discrete, others may in fact vary o...

    Authors: G. Provost, F. B. Lavoie, A. Larbi, TP. Ng, C. Tan Tze Ying, M. Chua, T. Fulop and A. A. Cohen
    Citation: Immunity & Ageing 2022 19:35
  5. The immune cell compartment of the mammalian brain changes dramatically and peripheral T cells infiltrate the brain parenchyma during normal aging. However, the mechanisms underlying age-related T cell infiltr...

    Authors: Xiaotao Zhang, Rui Wang, Haoran Chen, Chenghao Jin, Ziyang Jin, Jianan Lu, Liang Xu, Yunrong Lu, Jianmin Zhang and Ligen Shi
    Citation: Immunity & Ageing 2022 19:34
  6. Cellular changes in adaptive immune system accompany the process of aging and contribute to an aging-related immune phenotype (ARIP) characterized by decrease in naïve T-cells (TN) and increase in memory T-cells ...

    Authors: Ramya Ramasubramanian, Helen C. S. Meier, Sithara Vivek, Eric Klopack, Eileen M. Crimmins, Jessica Faul, Janko Nikolich-Žugich and Bharat Thyagarajan
    Citation: Immunity & Ageing 2022 19:33
  7. Telomerase, the enzyme capable of elongating telomeres, is usually restricted in human somatic cells, which contributes to progressive telomere shortening with cell-division and ageing. T and B-cells cells are...

    Authors: Pam S. Ellis, Raquel R. Martins, Emily J. Thompson, Asma Farhat, Stephen A. Renshaw and Catarina M. Henriques
    Citation: Immunity & Ageing 2022 19:31
  8. Authors: Grace M. Niemiro, Adriana M. Coletta, Nadia H. Agha, Preteesh Leo Mylabathula, Forrest L. Baker, Abenaa M. Brewster, Therese B. Bevers, Enrique Fuentes-Mattei, Karen Basen-Engquist, Emmanuel Katsanis, Susan C. Gilchrist and Richard J. Simpson
    Citation: Immunity & Ageing 2022 19:30

    The original article was published in Immunity & Ageing 2022 19:17

  9. Grass carp are an important farmed fish in China that are infected by many pathogens, especially grass carp reovirus (GCRV). Notably, grass carp showed age-dependent susceptibility to GCRV; that is, grass carp...

    Authors: Libo He, Xinyu Liang, Qian Wang, Cheng Yang, Yongming Li, Lanjie Liao, Zuoyan Zhu and Yaping Wang
    Citation: Immunity & Ageing 2022 19:28
  10. Influenza causes a serious infection in older individuals who are at the highest risk for mortality from this virus. Changes in the immune system with age are well known. This study used transcriptomic analysi...

    Authors: Ana M. Hernandez, Jim A. Mossman, Franklin R. Toapanta, Dana M. Previte, Ted M. Ross and Gerard J. Nau
    Citation: Immunity & Ageing 2022 19:27
  11. With increasing age, overall health declines while systemic levels of inflammatory mediators tend to increase. Although the underlying mechanisms are poorly understood, there is a wealth of data suggesting tha...

    Authors: Emilie Picard, Sarah Armstrong, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, George A. Kuchel, Janet E. McElhaney and Chris P. Verschoor
    Citation: Immunity & Ageing 2022 19:26
  12. Understanding mechanisms of pathologic neuroinflammation is essential for improving outcomes after central nervous system infections. Brain tissue-resident memory T cells (bTRM) are recruited during central nervo...

    Authors: Benjamin R. Cassidy, William E. Sonntag, Pieter J. M. Leenen and Douglas A. Drevets
    Citation: Immunity & Ageing 2022 19:25
  13. The existence of SARS-CoV-2 variants of concern (VOCs) in association with evidence of breakthrough infections despite vaccination resulted in the need for vaccine boosting. In elderly individuals, information...

    Authors: Chalerm Liwsrisakun, Supansa Pata, Witida Laopajon, Nuchjira Takheaw, Warawut Chaiwong, Juthamas Inchai, Chaicharn Pothirat, Chaiwat Bumroongkit, Athavudh Deesomchok, Theerakorn Theerakittikul, Atikun Limsukon, Pattraporn Tajarernmuang, Nutchanok Niyatiwatchanchai, Konlawij Trongtrakul, Kantinan Chuensirikulchai and Watchara Kasinrerk
    Citation: Immunity & Ageing 2022 19:24
  14. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of mutant hematopoietic stem cells, confers risk for multiple diseases of aging including hematologic cancer and cardiovascular...

    Authors: Md Mesbah Uddin, Ying Zhou, Alexander G. Bick, Bala Bharathi Burugula, Siddhartha Jaiswal, Pinkal Desai, Michael C. Honigberg, Shelly-Ann Love, Ana Barac, Kathleen M. Hayden, JoAnn E. Manson, Eric A. Whitsel, Charles Kooperberg, Pradeep Natarajan, Alexander P. Reiner and Jacob O. Kitzman
    Citation: Immunity & Ageing 2022 19:23
  15. Highly contagious respiratory diseases caused by viral infections are a constantly emerging threat, particularly the elderly with the higher risk of developing serious complications. Vaccines are the best stra...

    Authors: Jihyun Yang, Jaemoo Kim, Chaewon Kwak and Haryoung Poo
    Citation: Immunity & Ageing 2022 19:22
  16. Depression is considered to be an immune-related disease; however, previous studies have focused on inflammatory factors, and there is no conclusive conclusion on the relationships between immunoglobulins and ...

    Authors: Zhigao Sun, Jieqiong Lin, Yujie Zhang, Yao Yao, Zhenjun Huang, Yali Zhao, Pei Zhang and Shihui Fu
    Citation: Immunity & Ageing 2022 19:21
  17. NF-κB is generally recognized as an important regulator of ageing, through its roles in cellular senescence and inflammatory pathways. Activated in virtually all cell-cell communication networks of the immune ...

    Authors: Preeyaporn Songkiatisak, Shah Md Toufiqur Rahman, Mohammad Aqdas and Myong-Hee Sung
    Citation: Immunity & Ageing 2022 19:20
  18. It is generally accepted that aging has detrimental effects on conventional T cell responses to systemic infections. However, most pathogens naturally invade the body through mucosal barriers. Although mucosal...

    Authors: Camille Khairallah, Timothy H. Chu, Zhijuan Qiu, Jessica N. Imperato, Daniella Yang and Brian S. Sheridan
    Citation: Immunity & Ageing 2022 19:19
  19. NKT-like cells are T lymphocytes coexpressing several NK cell-associated receptors. They are effector lymphocytes of innate and adaptive immunity, and their number increases with age. The study aimed to analyz...

    Authors: Lucyna Kaszubowska, Jerzy Foerster and Zbigniew Kmieć
    Citation: Immunity & Ageing 2022 19:18
  20. Immunosenescence is described as age-associated changes within the immune system that are responsible for decreased immunity and increased cancer risk. Physically active individuals have fewer ‘senescent’ and ...

    Authors: Grace M Niemiro, Adriana M Coletta, Nadia H. Agha, Preteesh Leo Mylabathula, Forrest L. Baker, Abenaa M Brewster, Therese B Bevers, Enrique Fuentes-Mattei, Karen Basen-Engquist, Emmanuel Katsanis, Susan C Gilchrist and Richard J. Simpson
    Citation: Immunity & Ageing 2022 19:17

    The Correction to this article has been published in Immunity & Ageing 2022 19:30

  21. Amongst other systemic changes, aging leads to an immune dysfunction. On the molecular level, a hallmark of aging is telomere shortening. The functional relevance of telomerase, an enzyme capable of elongating...

    Authors: Diana M. Matthe, Oana-Maria Thoma, Tobias Sperka, Markus F. Neurath and Maximilian J. Waldner
    Citation: Immunity & Ageing 2022 19:16
  22. As we age, the functioning of the human immune system declines. The results of this are increases in morbidity and mortality associated with infectious diseases, cancer, cardiovascular disease, and neurodegene...

    Authors: Arttu Autio, Jalmari Kettunen, Tapio Nevalainen, Bryn Kimura and Mikko Hurme
    Citation: Immunity & Ageing 2022 19:15
  23. Despite the high incidence of fractures and pseudoarthrosis in the aged population, a potential role for the use of mesenchymal stem cells (MSCs) in the treatment of bone defects in elderly patients has not be...

    Authors: Hirohito Hirata, Ning Zhang, Masaya Ueno, Danial Barati, Junichi Kushioka, Huaishuang Shen, Masanori Tsubosaka, Masakazu Toya, Tzuhua Lin, Ejun Huang, Zhenyu Yao, Joy Y. Wu, Stefan Zwingenberger, Fan Yang and Stuart B. Goodman
    Citation: Immunity & Ageing 2022 19:14
  24. Chronic cytomegalovirus (CMV) infection has been postulated as a driver of chronic inflammation that has been associated with frailty and other age-related conditions in both HIV-infected (HIV+) and -uninfecte...

    Authors: Weiying Zhang, Huifen Li, Jay H. Bream, Tricia L. Nilles, Sean X. Leng and Joseph B. Margolick
    Citation: Immunity & Ageing 2022 19:13
  25. COVID-19 patients may experience “cytokine storm” when human immune system produces excessive cytokines/chemokines. However, it remains unclear whether early responses of inflammatory cytokines would lead to h...

    Authors: Xixi Jing, Min Xu, Deye Song, Tingting Yue, Yali Wang, Pan Zhang, Yanjun Zhong, Min Zhang, Tommy Tsan-Yuk Lam, Nuno Rodrigues Faria, Erik De Clercq and Guangdi Li
    Citation: Immunity & Ageing 2022 19:12
  26. γδ T cells are a highly versatile immune lineage involved in host defense and homeostasis, but questions remain around their heterogeneity, precise function and role during health and disease. We used multiparam...

    Authors: Amali Karunathilaka, Samuel Halstrom, Patricia Price, Michael Holt, Viviana P. Lutzky, Denise L. Doolan, Andreas Kupz, Scott C. Bell, Rachel M. Thomson, John J. Miles and Champa N. Ratnatunga
    Citation: Immunity & Ageing 2022 19:11
  27. Chronic inflammation might play a major role in the pathogenesis linking diabetes mellitus (DM) to cognition. In addition, DM might be the main driver of dementia risk. The purpose of the present study was to ...

    Authors: Yen-Chun Fan, Chia-Chi Chou, Bagas Suryo Bintoro, Kuo-Liong Chien and Chyi-Huey Bai
    Citation: Immunity & Ageing 2022 19:10
  28. COPD is associated with an abnormal lung immune response that leads to tissue damage and remodeling of the lung, but also to systemic effects that compromise immune responses. Cigarette smoking also impacts on...

    Authors: Juliana Ruiz Fernandes, Thalyta Nery Carvalho Pinto, Liã Barbara Arruda, Cibele Cristine Berto Marques da Silva, Celso Ricardo Fernandes de Carvalho, Regina Maria Carvalho Pinto, Alberto José da Silva Duarte and Gil Benard
    Citation: Immunity & Ageing 2022 19:9
  29. Rapamycin (Rapa), acarbose (ACA), and 17α-estradiol (17aE2, males only) have health benefits that increase lifespan of mice. Little is known about how these three agents alter the network of pathways downstrea...

    Authors: Lily Wink, Richard A. Miller and Gonzalo G. Garcia
    Citation: Immunity & Ageing 2022 19:8
  30. To investigate the role of cell senescence in systemic sclerosis (SSc), we analyzed telomere shortening (TS) in SSc patients and the effect of targeting DNA damage in the bleomycin model of skin fibrosis.

    Authors: Alicia Usategui, Cristina Municio, Elena G. Arias-Salgado, María Martín, Beatriz Fernández-Varas, Manuel J. Del Rey, Patricia Carreira, Antonio González, Gabriel Criado, Rosario Perona and José L. Pablos
    Citation: Immunity & Ageing 2022 19:7
  31. Elderly often show reduced immune functioning and can develop chronic low-grade inflammation. Why some elderly are more prone to become frail is unknown. We investigated whether frailty is associated with alte...

    Authors: Leonard Daniël Samson, Peter Engelfriet, W. M. Monique Verschuren, H. Susan J. Picavet, José A. Ferreira, Mary-lène de Zeeuw-Brouwer, Anne-Marie Buisman and A. Mieke H. Boots
    Citation: Immunity & Ageing 2022 19:5
  32. Older age could be a risk factor for suboptimal CD4+ T-cell recovery in HIV-infected patients despite successful viral suppression. However, evaluation of this effect could be confounded by age-related immune ...

    Authors: Jingxian Chen, Kehmia Titanji, Anandi N. Sheth, Rajesh Gandhi, Deborah McMahon, Ighovwerha Ofotokun, M. Neale Weitzmann, Kristina De Paris and Julie B. Dumond
    Citation: Immunity & Ageing 2022 19:4
  33. Memory B cells are an antigen-experienced B-cell population with the ability to rapidly differentiate into antibody-producing cells by recall responses. We recently found that dedicator of cytokinesis 11 (DOCK...

    Authors: Yuma Sugiyama, Mitsuhiro Fujiwara, Akihiko Sakamoto, Hiromichi Tsushima, Akihiko Nishikimi and Mitsuo Maruyama
    Citation: Immunity & Ageing 2022 19:2
  34. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) are readily available circulatory immunity markers that are associated with components ...

    Authors: Hui Zhang, Meng Hao, Zixin Hu, Yi Li, Xiaoyan Jiang, Jiucun Wang, Li Jin, Zuyun Liu, Xiaofeng Wang and Xuehui Sun
    Citation: Immunity & Ageing 2022 19:1
  35. Studies have shown that the decrease of osteogenic differentiation of bone marrow mesenchymal stem cells (MSC) is an important mechanism of osteoporosis. The object of this study was to explore the role and me...

    Authors: Guanghua Chen, Guizhi Huang, Han Lin, Xinyou Wu, Xiaoyan Tan and Zhoutao Chen
    Citation: Immunity & Ageing 2021 18:45
  36. The incidence of kidney transplantation performed in elderly patients has increased steadily recently. Higher risk of infection and mortality, but lower rate of rejection, are reported in older kidney transpla...

    Authors: Lei Wang, Christien Rondaan, Anoek A. E. de Joode, Elisabeth Raveling-Eelsing, Nicolaas A. Bos and Johanna Westra
    Citation: Immunity & Ageing 2021 18:43
  37. We, and others, have suggested that as the SARS-CoV-2 virus may modulate mitochondrial function, good mitochondrial reserve and health could be key in determining disease severity when exposed to this virus, a...

    Authors: Alistair V.W. Nunn, Geoffrey W. Guy, Stanley W. Botchway and Jimmy D. Bell
    Citation: Immunity & Ageing 2021 18:40
  38. There are currently > 600 million people over the age of 65 globally and this number is expected to double by the year 2050. Alcohol use among this population is on the rise, which is concerning as aging is as...

    Authors: Rachel H. McMahan, Kevin M. Najarro, Juliet E. Mullen, Madison T. Paul, David J. Orlicky, Holly J. Hulsebus and Elizabeth J. Kovacs
    Citation: Immunity & Ageing 2021 18:37

    The Correction to this article has been published in Immunity & Ageing 2021 18:39

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