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  1. Neovascular age-related macular degeneration (nAMD) is a major cause of blindness in the elderly. The disease is due to the growth of abnormal blood vessels into the macula, leading to the loss of central visi...

    Authors: Wen Deng, Caijiao Yi, Wei Pan, Jian Liu, Jinyan Qi, Juan Chen, Zengchao Zhou, Yiqin Duan, Xiangyan Ning, Jun Li, Changhua Ye, Zhongping Chen and Heping Xu
    Citation: Immunity & Ageing 2023 20:65
  2. Exercise is postulated to be a promising non-pharmacological intervention for the improvement of neurodegenerative disease pathology. However, the mechanism of beneficial effects of exercise on the brain remai...

    Authors: Hao Han, Yawei Zhao, Junda Du, Sushan Wang, Xuehan Yang, Weijie Li, Jiayi Song, Siwei Zhang, Ziyi Zhang, Yongfei Tan, Grant M. Hatch, Ming Zhang and Li Chen
    Citation: Immunity & Ageing 2023 20:63
  3. About 25% of patients with acute hepatitis C virus (HCV) infection show spontaneous clearance within the first six months of infection but may remain at risk of inflammaging, aging, and liver and non-liver dis...

    Authors: Rubén Martín-Escolano, Erick Joan Vidal-Alcántara, Javier Crespo, Pablo Ryan, Luis Miguel Real, Juan Ignacio Lazo-Álvarez, Joaquín Cabezas-González, Juan Macías, María Teresa Arias-Loste, Guillermo Cuevas, Ana Virseda-Berdices, Veronica Briz, Salvador Resino, María Ángeles Jiménez-Sousa and Amanda Fernández-Rodríguez
    Citation: Immunity & Ageing 2023 20:62
  4. Aging is a biological event that influences many organs and systems. Both sarcopenia and frailty syndrome refer to geriatric conditions with overlapping phenotypes. Many mechanisms are involved in the aging pr...

    Authors: Tomasz Kmiołek, Gabriela Filipowicz, Diana Bogucka, Anna Wajda, Adam Ejma-Multański, Barbara Stypińska, Ewa Modzelewska, Yana Kaliberda, Marcin Radkowski, Tomasz Targowski, Julia Wrona and Agnieszka Paradowska-Gorycka
    Citation: Immunity & Ageing 2023 20:61
  5. The involvement of the peripheral immune system in the etiology of neurodegenerative diseases has recently been emphasized. Genome-wide association studies (GWAS) have recently identified several candidate imm...

    Authors: S. R. Fatemi Langroudi, M. Zeinaly and F. Ajamian
    Citation: Immunity & Ageing 2023 20:59
  6. The aging lung is a complex process and influenced by various stressors, especially airborne pathogens and xenobiotics. Additionally, a lifetime exposure to antigens results in structural and functional change...

    Authors: Meng He and Jürgen Borlak
    Citation: Immunity & Ageing 2023 20:58

    The Correction to this article has been published in Immunity & Ageing 2024 21:8

  7. Immune responses to vaccination vary widely between individuals. The aim of this study was to identify health-related variables potentially underlying the antibody responses to SARS-CoV-2 vaccination in older ...

    Authors: Yunus Kuijpers, H. Susan J. Picavet, Lia de Rond, Mary-lène de Zeeuw-Brouwer, Ryanne Rutkens, Esther Gijsbers, Irene Slits, Peter Engelfriet, Anne-Marie Buisman and W. M. Monique Verschuren
    Citation: Immunity & Ageing 2023 20:57
  8. Sarcopenia is closely associated with gut dysbiosis. Probiotics alleviate gut dysbiosis. Therefore, we selected probiotics Lactobacillus paracasei P62 (Lp) and Bifidobacterium bifidum P61 (Bb), which suppressed m...

    Authors: Ji-Su Baek, Yoon-Jung Shin, Xiaoyang Ma, Hee-Seo Park, Yun-Ha Hwang and Dong-Hyun Kim
    Citation: Immunity & Ageing 2023 20:56
  9. Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating...

    Authors: Bernardo Abel Cedeno-Veloz, Lucía Lozano-Vicario, Fabricio Zambom-Ferraresi, Joaquín Fernández-Irigoyen, Enrique Santamaría, Alba Rodríguez-García, Roman Romero-Ortuno, Jaime Mondragon-Rubio, Javier Ruiz-Ruiz, Robinson Ramírez-Vélez, Mikel Izquierdo and Nicolás Martínez-Velilla
    Citation: Immunity & Ageing 2023 20:55
  10. Hip fractures in the elderly have significant consequences, stemming from the initial trauma and subsequent surgeries. Hidden blood loss and stress due to concealed injury sites could impact the whole osteoimm...

    Authors: Yining Lu, Yang Luo, Qi Zhang, Wei Chen, Ning Zhang, Ling Wang and Yingze Zhang
    Citation: Immunity & Ageing 2023 20:54
  11. Increased age is a risk factor for the development and progression of retinal diseases including age-related macular degeneration (AMD). Understanding the changes that occur in the eye due to aging is importan...

    Authors: Margarete M. Karg, May Moorefield, Emma Hoffmann, Hannah Philipose, Drenushe Krasniqi, Cindy Hoppe, Daisy Y. Shu, Shintaro Shirahama, Bruce R. Ksander and Magali Saint-Geniez
    Citation: Immunity & Ageing 2023 20:53

    The Correction to this article has been published in Immunity & Ageing 2023 20:60

  12. Age-associated deterioration of the immune system contributes to a chronic low-grade inflammatory state known as “inflammaging” and is implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD). W...

    Authors: Neriman Eren, Susanna Gerike, Berk Üsekes, Oliver Peters, Nicoleta-Carmen Cosma and Julian Hellmann-Regen
    Citation: Immunity & Ageing 2023 20:52
  13. Adipose-derived stem cells (ADSC) are multipotent cells implicated in tissue homeostasis. Obesity represents a chronic inflammatory disease associated with metabolic dysfunction and age-related mechanisms, wit...

    Authors: L K Grun, R M Maurmann, J N Scholl, M E Fogaça, C R R Schmitz, C K Dias, J Gasparotto, A V Padoin, C C Mottin, F Klamt, F Figueiró, M H Jones, E C Filippi-Chiela, F C R Guma and F M Barbé-Tuana
    Citation: Immunity & Ageing 2023 20:51
  14. Preclinical models are often used for cancer studies and evaluation of novel therapeutics. The relevance of these models has vastly improved with mice bearing a human immune system, especially in the context o...

    Authors: Joel H. L. Tan, You Yi Hwang, Hui Xian Chin, Min Liu, Sue Yee Tan and Qingfeng Chen
    Citation: Immunity & Ageing 2023 20:49
  15. Primary Sjögren’s syndrome (pSS) is a common chronic systemic autoimmune disorder which primarily affects the exocrine glands. Patients may have extraglandular disease involving multiple organs, including the ...

    Authors: Nan Duan, Zhiyan Li, Yong Fan, Yaping Jiang and Haixia Li
    Citation: Immunity & Ageing 2023 20:48
  16. Obesity is associated with chronic low-grade inflammation, which is underpinned by the presence of elevated levels of circulating proinflammatory cytokines in obese individuals. Due to the close relationship b...

    Authors: Pia Prechtl, Timo Schmitz, Nicole Pochert, Claudia Traidl-Hoffmann, Jakob Linseisen, Christa Meisinger and Dennis Freuer
    Citation: Immunity & Ageing 2023 20:47
  17. Neutrophils and lymphocytes represent the larger percentage of all white blood cells, they vary with age, with a progressive increase of the ratio in the first years of life, and then tend to remain at similar...

    Authors: Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Stefania Bandinelli, Antimo Moretti, Giovanni Iolascon, Eleonora Sparvieri, Domiziano Tarantino and Luigi Ferrucci
    Citation: Immunity & Ageing 2023 20:46
  18. Fatty degeneration of thymus (or thymus involution) has long been considered a normal ageing process. However, there is emerging evidence that thymic involution is linked to T cell aging, chronic inflammation ...

    Authors: Mårten Sandstedt, Rosanna W S Chung, Camilla Skoglund, Anna K. Lundberg, Carl Johan Östgren, Jan Ernerudh and Lena Jonasson
    Citation: Immunity & Ageing 2023 20:45
  19. Fasting is known to influence the immune functions of leukocytes primarily by regulating their mobilization and redistribution between the bone marrow and the peripheral tissues or circulation, in particular v...

    Authors: Yixuan Fang, Jiawei Qian, Li Xu, Wen Wei, Wenwen Bu, Suping Zhang, Yaqi Lv, Lei Li, Chen Zhao, Xueqin Gao, Yue Gu, Li Wang, Zixing Chen, Xiao Wang, Ruizhi Zhang, Youjia Xu…
    Citation: Immunity & Ageing 2023 20:44
  20. Women/females report more adverse events (AE) following immunization than men/males for many vaccines, including the influenza and COVID-19 vaccines. This discrepancy is often dismissed as a reporting bias, ye...

    Authors: Janna R. Shapiro, Kumba Seddu, Han-Sol Park, John S. Lee, Patrick S. Creisher, Anna Yin, Patrick Shea, Helen Kuo, Huifen Li, Engle Abrams, Sean X. Leng, Rosemary Morgan and Sabra L. Klein
    Citation: Immunity & Ageing 2023 20:43
  21. Coronavirus disease 2019 (COVID-19) remains a threat to vulnerable populations such as long-term care facility (LTCF) residents, who are often older, severely frail, and have multiple comorbidities. Although a...

    Authors: Tomoyuki Kakugawa, Keiko Doi, Yuichi Ohteru, Hiroyuki Kakugawa, Keiji Oishi, Masahiro Kakugawa, Tsunahiko Hirano, Yusuke Mimura and Kazuto Matsunaga
    Citation: Immunity & Ageing 2023 20:42
  22. Traumatic brain injury (TBI) is a leading cause of death and long-term disability worldwide. In addition to primary brain damage, systemic immune alterations occur, with evidence for dysregulated immune respon...

    Authors: Marta Magatti, Francesca Pischiutta, Fabrizio Ortolano, Anna Pasotti, Enrico Caruso, Anna Cargnoni, Andrea Papait, Franco Capuzzi, Tommaso Zoerle, Marco Carbonara, Nino Stocchetti, Stefano Borsa, Marco Locatelli, Elisa Erba, Daniele Prati, Antonietta R Silini…
    Citation: Immunity & Ageing 2023 20:41
  23. Lower respiratory infections are a leading cause of severe morbidity and mortality among older adults. Despite ubiquitous exposure to common respiratory pathogens throughout life and near universal seropositiv...

    Authors: Olivia B. Parks, Taylor Eddens, Jorna Sojati, Jie Lan, Yu Zhang, Tim D. Oury, Manda Ramsey, John J. Erickson, Craig A. Byersdorfer and John V. Williams
    Citation: Immunity & Ageing 2023 20:40
  24. More and more evidences are proving that microglia play a crucial role in the pathogenesis of Alzheimer’s disease (AD) and the plasma Aβ1-42 levels significantly increased 15 years before the onset of dominantly ...

    Authors: Chunrong Li, Kangding Liu, Jie Zhu and Feiqi Zhu
    Citation: Immunity & Ageing 2023 20:39
  25. Seasonal influenza causes significant morbidity and mortality with a disproportionately high disease burden in older adults. Strain-specific hemagglutination-inhibition (HAI) antibody titer is a well-establish...

    Authors: Bettina Wunderlich, Thomas Laskow, Huifen Li, Li Zhang, Engle Abrams, Jing Tian, Jun Yu, Yiyin Chen, Juliette Tavenier, Yushu Huang, Kawsar Talaat, Jay H. Bream, Qian-Li Xue, Graham Pawelec and Sean X. Leng
    Citation: Immunity & Ageing 2023 20:38
  26. Older adults are more vulnerable to seasonal influenza than younger adults. The immune responses of older persons to the influenza vaccine are usually poorer than those of young individuals, which is hypothesi...

    Authors: Tongling Xiao, Miaomiao Wei, Xiaokun Guo, Yu Zhang, Zhongyan Wang, Xiaoshuang Xia, Xuemei Qi, Lin Wang, Xin Li and Sean X. Leng
    Citation: Immunity & Ageing 2023 20:37
  27. Evidence has linked self-reported sedentary behavior (SB) and physical activity (PA) with cognitive impairment; however, the underlying mechanisms are poorly understood. We examined the associations of the acc...

    Authors: Yongxiang Wang, Qi Han, Xiaolei Han, Yi Dong, Ming Mao, Chaoqun Wang, Xiaojie Wang, Shi Tang, Cuicui Liu, Yuanjing Li, Tingting Hou, Lin Cong, Yifeng Du and Chengxuan Qiu
    Citation: Immunity & Ageing 2023 20:36
  28. Immune function in the genital mucosa balances reproduction with protection against pathogens. As women age, genital infections, and gynecological cancer risk increase, however, the mechanisms that regulate ce...

    Authors: Siddharth Parthasarathy, Zheng Shen, Francisco J. Carrillo-Salinas, Vidya Iyer, Alison Vogell, Diego Illanes, Charles R. Wira and Marta Rodriguez-Garcia
    Citation: Immunity & Ageing 2023 20:34
  29. Frailty is an intermediate and reversible geriatric syndrome that often precedes dependence. Therefore, its identification is essential to prevent dependence. Several molecules have been proposed as biomarkers...

    Authors: Leire Iparraguirre, Ainhoa Alberro, Saioa GS Iñiguez, Maider Muñoz-Culla, Itziar Vergara, Ander Matheu and David Otaegui
    Citation: Immunity & Ageing 2023 20:33
  30. Since the beginning of SARS-CoV2 pandemic, the mortality rate among elderly patients (60–90 years) has been around 50%, so age has been a determining factor of a worse COVID-19 prognosis. Associated with age, ...

    Authors: M. S. Espinar-Buitrago, L. Tarancon-Diez, E. Vazquez-Alejo, E. Magro-Lopez, M. Genebat, F. Romero-Candau, M. Leal and M. A. Muñoz-Fernandez
    Citation: Immunity & Ageing 2023 20:32
  31. Human aging is characterized by a state of chronic inflammation, termed inflammaging, for which the causes are incompletely understood. It is known, however, that macrophages play a driving role in establishin...

    Authors: Alexandre Poirier, Chenyue Wu, Ana Maria Hincapie, Zuzet Martinez-Cordova, Belma Melda Abidin and Michel L. Tremblay
    Citation: Immunity & Ageing 2023 20:31
  32. Adjuvanted inactivated influenza vaccine (aIIV) and high-dose inactivated influenza vaccine (HD-IIV) are U.S.-licensed for adults aged ≥ 65 years. This study compared serum hemagglutination inhibition (HAI) an...

    Authors: Kenneth E. Schmader, Christine K. Liu, Brendan Flannery, Wes Rountree, Heidi Auerbach, Elizabeth D. Barnett, Elizabeth P. Schlaudecker, Christopher A. Todd, Marek Poniewierski, Mary A. Staat, Theresa Harrington, Rongxia Li, Karen R. Broder and Emmanuel B. Walter
    Citation: Immunity & Ageing 2023 20:30
  33. Progressive age-associated change in frequencies and functional capacities of immune cells is known as immunosenescence. Despite data linking chronic environmental, physiological, and psychosocial stressors wi...

    Authors: Ryan G. Snodgrass, Xiaowen Jiang, Charles B. Stephensen and Kevin D. Laugero
    Citation: Immunity & Ageing 2023 20:29
  34. Age-associated impairments of immune response and inflammaging likely contribute to poor vaccine efficacy. An appropriate balance between activation of immune memory and inflammatory response may be more effec...

    Authors: Kathleen A. Ross, April M. Tingle, Sujata Senapati, Kaitlyn G. Holden, Michael J. Wannemuehler, Surya K. Mallapragada, Balaji Narasimhan and Marian L. Kohut
    Citation: Immunity & Ageing 2023 20:28
  35. TDP-43 is an important DNA/RNA-binding protein that is associated with age-related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); however, its pathome...

    Authors: Wenkai Yue, Xue Deng, Zhao Wang, Mingsheng Jiang, Rirong Hu, Yongjia Duan, Qiangqiang Wang, Jihong Cui and Yanshan Fang
    Citation: Immunity & Ageing 2023 20:27
  36. Various autoimmune responses increase with age, but the underlying mechanism is not clear. In this study, we used CD4+ T cells expressing a transgenic T cell receptor specific for desmoglein 3 (Dsg3), which is th...

    Authors: Hisato Iriki, Miho Mukai, Yasuhiko Asahina, Yoko Kubo, Hiromi Ito, Masayuki Amagai and Hayato Takahashi
    Citation: Immunity & Ageing 2023 20:26
  37. Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psychological, behavioral, and social processes. Aging entails changes in the immune system ...

    Authors: Danay Saavedra, Ana Laura Añé-Kourí, Nir Barzilai, Calogero Caruso, Kyung-Hyun Cho, Luigi Fontana, Claudio Franceschi, Daniela Frasca, Nuris Ledón, Laura J. Niedernhofer, Karla Pereira, Paul D. Robbins, Alexa Silva, Gisela M. Suarez, Wim Vanden Berghe, Thomas von Zglinicki…
    Citation: Immunity & Ageing 2023 20:25
  38. Dementia and frailty are common age-related syndromes often linked to chronic inflammation. Identifying the biological factors and pathways that contribute to chronic inflammation is crucial for developing new...

    Authors: Lolita S. Nidadavolu, Danielle Feger, Diefei Chen, Yuqiong Wu, Francine Grodstein, Alden L. Gross, David A. Bennett, Jeremy D. Walston, Esther S. Oh and Peter M. Abadir
    Citation: Immunity & Ageing 2023 20:24
  39. Pain in Fabry disease (FD) is generally accepted to result from neuronal damage in the peripheral nervous system as a consequence of excess lipid storage caused by alpha-galactosidase A (α-Gal A) deficiency. S...

    Authors: Jeiny Luna Choconta, Verena Labi, Cristiana Dumbraveanu, Theodora Kalpachidou, Kai K. Kummer and Michaela Kress
    Citation: Immunity & Ageing 2023 20:22
  40. Morphological and functional alterations in aging reproductive organs result in decreased male fertility. The epididymis functions as the transition region for post-testicular sperm maturation. And we have pre...

    Authors: Jintao Zhuang, Xiangping Li, Jiahui Yao, Xiangzhou Sun, Jiumin Liu, Hua Nie, Yang Hu, Xiangan Tu, Huang Liu, Weibing Qin and Yun Xie
    Citation: Immunity & Ageing 2023 20:21
  41. Current influenza vaccines deliver satisfactory results in young people but are less effective in the elderly. Development of vaccines for an ever-increasing aging population has been an arduous challenge due ...

    Authors: Bo Ryoung Park, Ramireddy Bommireddy, David Hyunjung Chung, Ki-Hye Kim, Jeeva Subbiah, Yu-Jin Jung, Noopur Bhatnagar, Christopher D. Pack, Sampath Ramachandiran, Shaker J.C. Reddy, Periasamy Selvaraj and Sang-Moo Kang
    Citation: Immunity & Ageing 2023 20:20
  42. Age-related accumulation of highly differentiated CD8+ effector memory re-expressing CD45RA (EMRA) T-cells and disruption of the kynurenine (KYN) pathway are associated with chronic inflammation and the developme...

    Authors: Tim Konstantin Boßlau, Paulina Wasserfurth, Thomas Reichel, Christopher Weyh, Jana Palmowski, Josefine Nebl, Niklas Joisten, Sergen Belen, Alexander Schenk, Andreas Hahn, Philipp Zimmer and Karsten Krüger
    Citation: Immunity & Ageing 2023 20:19
  43. Aging is associated with progressive declines in immune responses leading to increased risk of severe infection and diminished vaccination responses. Influenza (flu) is a leading killer of older adults despite...

    Authors: Dominique E. Martin, Andreia N. Cadar, Hunter Panier, Blake L. Torrance, George A. Kuchel and Jenna M. Bartley
    Citation: Immunity & Ageing 2023 20:18
  44. Advanced age is one of the significant risk determinants for coronavirus disease 2019 (COVID-19)-related mortality and for long COVID complications. The contributing factors may include the age-related dynamic...

    Authors: Ludmila Müller and Svetlana Di Benedetto
    Citation: Immunity & Ageing 2023 20:17
  45. Immunosenescence is a complex process characterized by an age-related remodelling of immune system. The prominent effects of the immunosenescence process is the thymic involution and, consequently, the decreas...

    Authors: Ersilia Paparazzo, Silvana Geracitano, Vincenzo Lagani, Luigi Citrigno, Denise Bartolomeo, Mirella Aurora Aceto, Francesco Bruno, Raffaele Maletta, Giuseppe Passarino and Alberto Montesanto
    Citation: Immunity & Ageing 2023 20:16
  46. A wide spectrum of changes occurs in the brain with age, from molecular to morphological aspects, and inflammation accompanied by mitochondria dysfunction is one of the significant factors associated with age....

    Authors: Kaiwu He, Lulin Nie, Tahir Ali, Zizhen Liu, Weifen Li, Ruyan Gao, Zena Zhang, Jianjun Liu, Zhongliang Dai, Yongmei Xie, Zaijun Zhang, Gongping Liu, Ming Dong, Zhi-Jian Yu, Shupeng Li and Xifei Yang
    Citation: Immunity & Ageing 2023 20:15

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