McElhaney JE, Effros RB: Immunosenescence: what does it mean to health outcomes in older adults?. Curr Opin Immunol. 2009, 21: 418-424.
Article
PubMed Central
CAS
PubMed
Google Scholar
Weinberger B, Schirmer M, MatteucciGothe R, Siebert U, Fuchs D, Grubeck-Loebenstein B: Recall responses to tetanus and diphtheria vaccination are frequently insufficient in elderly persons. PLoS One. 2013, 8: e82967-
Article
PubMed Central
PubMed
Google Scholar
Pawelec G, Solana R: Immunosenescence. Immunol Today. 1997, 10: 514-516.
Article
Google Scholar
Shaw AC, Goldstein DR, Montgomery RR: Age-dependent dysregulation of innate immunity. Nat Rev Immunol. 2013, 13: 875-887.
Article
PubMed Central
CAS
PubMed
Google Scholar
Camous X, Pera A, Solana R, Larbi A: NK cells in healthy aging and age-associated diseases. J Biomed Biotechnol. 2012, 2012: 195956-
Article
PubMed Central
PubMed
Google Scholar
Gayoso I, Sanchez-Correa B, Campos C, Alonso C, Pera A, Casado JG, Morgado S, Tarazona R, Solana R: Immunosenescence of human natural killer cells. J Innate Immun. 2011, 3: 337-343.
Article
CAS
PubMed
Google Scholar
Agrawal A, Tay J, Ton S, Agrawal S, Gupta S: Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA. J Immunol. 2009, 182: 1138-1145.
Article
PubMed Central
CAS
PubMed
Google Scholar
Panda A, Qian F, Mohanty S, van Duin D, Newman FK, Zhang L, Chen S, Towle V, Belshe RB, Fikrig E, Allore HG, Montgomery RR, Shaw AC: Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol. 2010, 184: 2518-2527.
Article
CAS
PubMed
Google Scholar
Wong C, Goldstein DR: Impact of aging on antigen presentation cell function of dendritic cells. Curr Opin Immunol. 2013, 25: 535-541.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fülöp T, Larbi A, Pawelec G: Human T cell aging and the impact of persistent viral infections. Front Immunol. 2013, 4: 271-
Article
PubMed Central
PubMed
Google Scholar
Haynes L, Maue AC: Effects of aging on T cell function. Curr Opin Immunol. 2009, 21: 414-417.
Article
PubMed Central
CAS
PubMed
Google Scholar
Krone CL, van de Groep K, Trzciński K, Sanders EA, Bogaert D: Immunosenescence and pneumococcal disease: an imbalance in host-pathogen interactions. Lancet Respir Med. 2014, 2: 141-153.
Article
PubMed
Google Scholar
Eilers R, Krabbe PF, van Essen TG, Suijkerbuijk A, van Lier A, de Melker HE: Assessment of vaccine candidates for persons aged 50 and older: a review. BMC Geriatr. 2013, 13: 32-doi: 10.1186/1471-2318-13-32
Article
PubMed Central
PubMed
Google Scholar
Goodwin K, Viboud C, Simonsen L: Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine. 2006, 24: 1159-1169.
Article
CAS
PubMed
Google Scholar
Kogut I, Scholz JL, Cancro MP, Cambier JC: B cell maintenance and function in aging. Semin Immunol. 2012, 24: 342-349.
Article
CAS
PubMed
Google Scholar
Ademokun A, Wu YC, Dunn-Walters D: The ageing B cell population: composition and function. Biogerontology. 2010, 11: 125-137.
Article
PubMed
Google Scholar
Frasca D, Blomberg BB: Aging affects human B cell responses. J Clin Immunol. 2011, 31: 430-435.
Article
PubMed
Google Scholar
Buffa S, Bulati M, Pellicanò M, Dunn-Walters DK, Wu YC, Candore G, Vitello S, Caruso C, Colonna-Romano G: B cell immunosenescence: different features of naive and memory B cells in elderly. Biogerontology. 2011, 12: 473-483.
Article
CAS
PubMed
Google Scholar
Frasca D, Diaz A, Romero M, Landin AM, Phillips M, Lechner SC, Ryan JG, Blomberg BB: Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans. Vaccine. 2010, 28: 8077-8084.
Article
PubMed Central
CAS
PubMed
Google Scholar
Eaton SM, Burns EM, Kusser K, Randall TD, Haynes L: Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses. J Exp Med. 2004, 200: 1613-1622.
Article
PubMed Central
CAS
PubMed
Google Scholar
Haynes L, Eaton SM: The effect of age on the cognate function of CD4+ T cells. Immunol Rev. 2005, 205: 220-228.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lefebvre JS, Maue AC, Eaton SM, Lanthier PA, Tighe M, Haynes L: The aged microenvironment contributes to the age-related functional defects of CD4 T cells in mice. Aging Cell. 2012, 11: 732-740.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tangye SG, Ma CS, Brink R, Deenick EK: The good, the bad and the ugly - TFH cells in human health and disease. Nat Rev Immunol. 2013, 13: 412-426.
Article
CAS
PubMed
Google Scholar
Crotty S: Follicular helper CD4 T cells (TFH). Annu Rev Immunol. 2011, 29: 621-663.
Article
CAS
PubMed
Google Scholar
Nurieva RI, Chung Y, Martinez GJ, Yang XO, Tanaka S, Matskevitch TD, Wang YH, Dong C: Bcl6 mediates the development of T follicular helper cells. Science. 2009, 325: 1001-1005.
Article
PubMed Central
CAS
PubMed
Google Scholar
Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, Dent AL, Craft J, Crotty S: Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science. 2009, 325: 1006-10010.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, Wang YH, Watowich SS, Jetten AM, Tian Q, Dong C: Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity. 2008, 29: 138-149.
Article
PubMed Central
CAS
PubMed
Google Scholar
Morita R, Schmitt N, Bentebibel SE, Ranganathan R, Bourdery L, Zurawski G, Foucat E, Dullaers M, Oh S, Sabzghabaei N, Lavecchio EM, Punaro M, Pascual V, Banchereau J, Ueno H: Human blood CXCR5 (+) CD4 (+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity. 2011, 34: 108-121.
Article
PubMed Central
CAS
PubMed
Google Scholar
McDonald KG, Leach MR, Huang C, Wang C, Newberry RD: Aging impacts isolated lymphoid follicle development and function. Immun Ageing. 2011, 8: 1-
Article
PubMed Central
CAS
PubMed
Google Scholar
Hirokawa K, Utsuyama M, Hayashi Y, Kitagawa M, Makinodan T, Fulop T: Slower immune system aging in women versus men in the Japanese population. Immun Ageing. 2013, 10: 19-
Article
PubMed Central
PubMed
Google Scholar
Provinciali M, Moresi R, Donnini A, Lisa RM: Reference values for CD4+ and CD8+ T lymphocytes with naïve or memory phenotype and their association with mortality in the elderly. Gerontology. 2009, 55 (3): 314-321.
Article
PubMed
Google Scholar
Chng WJ, Tan GB, Kuperan P: Establishment of adult peripheral blood lymphocyte subset reference range for an Asian population by single-platform flow cytometry: influence of age, sex, and race and comparison with other published studies. Clin Diagn Lab Immunol. 2004, 11: 168-173.
PubMed Central
PubMed
Google Scholar
Wertheimer AM, Bennett MS, Park B, Uhrlaub JL, Martinez C, Pulko V, Currier NL, Nikolich-Žugich D, Kaye J, Nikolich-Žugich J: Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans. J Immunol. 2014, 192: 2143-2155.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sallusto F, Geginat J, Lanzavecchia A: Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol. 2004, 22: 745-763.
Article
CAS
PubMed
Google Scholar
Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B: CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med. 2000, 192: 1553-1562.
Article
PubMed Central
CAS
PubMed
Google Scholar
Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M, Förster R: Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med. 2000, 192: 1545-1552.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kim CH, Rott LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC: Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. J Exp Med. 2001, 193: 1373-1381.
Article
PubMed Central
CAS
PubMed
Google Scholar
Farber DL, Yudanin NA, Restifo NP: Human memory T cells: generation, compartmentalization and homeostasis. Nat Rev Immunol. 2014, 14: 24-35.
Article
PubMed Central
CAS
PubMed
Google Scholar
Linterman MA, Vinuesa CG: Signals that influence T follicular helper cell differentiation and function. Semin Immuno Pathol. 2010, 32: 183-196.
Article
CAS
Google Scholar
Weng NP, Akbar AN, Goronzy J: CD28 (-) T cells: their role in the age-associated decline of immune function. Trends Immunol. 2009, 30: 306-312.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yi JS, Cox MA, Zajac AJ: Interleukin-21: a multifunctional regulator of immunity to infections. Microbes Infect. 2010, 12: 1111-1119.
Article
PubMed Central
CAS
PubMed
Google Scholar
Liu SM, King C: IL-21-producing Th cells in immunity and autoimmunity. J Immunol. 2013, 191: 3501-3506.
Article
CAS
PubMed
Google Scholar
Agrawal A, Su H, Chen J, Osann K, Agrawal S, Gupta S: Increased IL-21 secretion by aged CD4 + T cells is associated with prolonged STAT-4 activation and CMV seropositivity. Aging (Albany NY). 2012, 4: 648-659.
CAS
Google Scholar
Onoda T, Rahman M, Nara H, Araki A, Makabe K, Tsumoto K, Kumagai I, Kudo T, Ishii N, Tanaka N, Sugamura K, Hayasaka K, Asao H: Human CD4+ central and effector memory T cells produce IL-21: effect on cytokine-driven proliferation of CD4+ T cell subsets. Int Immunol. 2007, 19: 1191-1199.
Article
CAS
PubMed
Google Scholar
Yu M, Li G, Lee WW, Yuan M, Cui D, Weyand CM, Goronzy JJ: Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age. Proc Natl Acad Sci U S A. 2012, 109: E879-E888.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sarra M, Franzè E, Pallone F, Monteleone G: Targeting interleukin-21 in inflammatory diseases. Expert Opin Ther Targets. 2011, 15: 695-702.
Article
CAS
PubMed
Google Scholar
Lee N, Shin MS, Kang I: T-cell biology in aging, with a focus on lung disease. J Gerontol A Biol Sci Med Sci. 2012, 67: 254-263.
Article
PubMed
Google Scholar
Lee JS, Lee WW, Kim SH, Kang Y, Lee N, Shin MS, Kang SW, Kang I: Age-associated alteration in naive and memory Th17 cell response in humans. Clin Immunol. 2011, 140: 84-91.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fang FQ, Fan QS, Yang ZJ, Peng YB, Zhang L, Mao KZ, Zhang Y, Ji YH: Incidence of cytomegalovirus infection in Shanghai, China. Clin Vaccine Immunol. 2009, 16: 1700-1703.
Article
PubMed Central
CAS
PubMed
Google Scholar